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Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder


To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.

Type Journal
ISBN 0148-7299 (Print)
Authors Adams, L. J.;Salmon, J.;Donald, J. A.;Mitchell, P. B.;Schofield, P. R. :
Publisher Name AM J MED GENET B
Published Date 1996-01-01 00:00:00
Published Volume 67
Published Issue 5
Published Pages 485-7
Status Published In-print