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New 'micro-organ' was hiding in plain sight

MEDIA RELEASE: Aug 23, 2018 06:30 AM
For the first time in decades, researchers have identified a new anatomical structure within the immune system – and they say it’s an important step towards understanding how to make better vaccines.

Osteoporosis

May 08, 2013 12:45 PM
Existing methods for low cost lenses using parallel mold stamping and high temperature reflow requires complex engineering controls to produce high quality lenses. These manufacturing techniques rely on expensive equipme...
AIM/HYPOTHESIS: We determined the effect of exercise training on insulin sensitivity and muscle lipids (triglyceride [TG(m)] and long-chain fatty acyl CoA [LCACoA] concentration) in patients with Type 2 diabetes. METHODS...
MicroRNAs (miRNAs) are approximately 22-nt small RNAs that are important regulators of mRNA turnover and translation. Recent studies have shown the importance of the miRNA pathway in HIV-1 infection, particularly in main...
Melanomas have high levels of genomic instability that can contribute to poor disease prognosis. Here, we report a novel defect of the ATM-dependent cell cycle checkpoint in melanoma cell lines that promotes genomic inst...
Next-generation sequencing (NGS) provides a broad investigation of the genome, and it is being readily applied for the diagnosis of disease-associated genetic features. However, the interpretation of NGS data remains cha...
Parkinson's Disease (PD) is a complex, chronic, progressive, and debilitating neurodegenerative disorder. Neither a cure nor effective long-term therapy exist and the lack of knowledge of the molecular mechanisms respons...
Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte behavior remain incomple...

Research integrity

Jul 04, 2013 02:37 AM

Potential gene therapy for patients with rare disease

MEDIA RELEASE: Apr 11, 2012 02:05 PM
Australian scientists have discovered that a biological phenomenon known as ‘somatic reversion’, when an abnormal gene spontaneously becomes normal again, explains why some patients with a rare genetic disorder live ...
High-throughput experimental technologies often identify dozens to hundreds of genes related to, or changed in, a biological or pathological process. From these genes one wants to identify biological pathways that may be...
Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer. These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signa...
Garvan researchers have uncovered facts that take us a step closer towards understanding Prader-Willi Syndrome, a harrowing genetic disorder that causes insatiable appetite for life.
A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, ...