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CD4(+) T cells can differentiate into numerous subsets characterized by expression of a suite of cytokines and effector molecules that endow them with specialized functions. By mediating the differentiation of B cells in...
Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis. This open-label observational study investigated metformin and lactate concentrations in patients w...
Calcium absorption, assessed by a double isotope method, was found to be impaired in postmenopausal women with rheumatoid arthritis of recent onset (mean 14.2 months) compared with controls. Circulating levels of 1,25-di...
Variations in mammary ductal side branching patterns are known to occur between different strains of mice and this is related to the rate of spontaneous mammary cancers, which are increased in those strains which show hi...
The insulin release after an oral glucose load is both earlier and greater than would be expected from the glycemic stimulus. This augmentation of insulin release has been attributed to humoral factors from the gut.It ha...

Osteoporosis in Australia

May 08, 2013 12:44 PM
Metformin reduces the incidence of progression to type 2 diabetes in humans with obesity or impaired glucose tolerance. We used an animal model to investigate whether metformin could prevent acute lipid-induced insulin r...
To avoid the generation of pathogenic autoantibodies, self-reactive lymphocytes are deleted at several distinct checkpoints during B cell maturation. BAFF is required for mature B cell development and survival but causes...
OBJECTIVE: Although growth hormone (GH)-induced changes in fat and protein metabolism are likely to underlie changes in body composition, the relationship has not been clearly defined. The aim was to study the effects of...
Glucose is the principal energy substrate for the brain and studies have shown that the brain is able to increase glucose availability in the face of glucose starvation (neuroglycopaenia). The mechanisms, believed to be ...
Analysis of cancer methylomes has dramatically changed our concept of the potential of diagnostic and prognostic methylation biomarkers in disease stratification. Through whole-genome methylation capture sequencing of tr...
We describe two young men with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing hypopituitarism. The first patient presented acutely unwell with headache and vomiting associated with anterior and ...
The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a dietmicrobiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.