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Understanding how a key group of immune cells is born

MEDIA RELEASE: Jul 06, 2012 04:00 PM
A Garvan scientist, in collaboration with colleagues from Switzerland, has demonstrated for the first time how an important class of immune cells, ‘Follicular dendritic cells’, essential for the development of antibo...

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Jan 02, 2014 11:48 AM
Spontaneously hypertensive rats (SHR) are the most extensively used animal model for genetic hypertension, increased stroke damage, and insulin resistance syndromes; however, the identification of target genes has proved...
Determination of the functional reserve of the anterior pituitary gland requires the serial measurement of hormones released from the pituitary by specific stimuli. Individually, insulin-induced hypoglycaemia, thyrotroph...
Paspaley recently released the 'Kimberley Bracelet' to support Garvan’s cancer research. 20% of the purchase price is donated to Garvan, with Paspaley customers choosing which area of cancer research to support.
Chromosome locus 11q13 is frequently amplified in a number of human cancers including carcinoma of the breast where up to 15% carry this chromosomal abnormality. Originally 11q13 amplification was thought to involve a si...
The relationship between body mass index (BMI) and fracture risk is controversial. We sought to investigate the effect of collinearity between BMI and bone mineral density (BMD) on fracture risk, and to estimate the dire...
The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of ...
Epstein-Barr virus (EBV) persists in healthy virus carriers within the immunoglobulin (Ig)D(-)CD27(+) (class-switched) memory B-cell compartment that normally arises through antigen stimulation and germinal center transi...
Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in ...
Lymphocyte activation requires the integration of signals provided by the extracellular environment in the form of cell-like interactions and soluble factors, mainly cytokines. Engagement of specific receptors by these l...
To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City...
Pathogenicity assessment of DNA variants in disease genes to explain their clinical consequences is an integral component of diagnostic molecular testing. The International Society for Gastrointestinal Hereditary Tumors ...
Germ line or hypothalamus-specific deletion of Y2 receptors in mice results in a doubling of trabecular bone volume. However, the specific mechanism by which deletion of Y2 receptors increases bone mass has not yet been ...