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Sulfonylureas are potent hypoglycemic agents; however, their mechanism of action remains incompletely understood. Recent data indicate that hypothalamic norepinephrine (NE) plays a major role in mediating the central neu...
The number and type of receptors present at the postsynaptic membrane determine the response to the neurotransmitter released from the presynaptic terminal. Because most neurons receive multiple and distinct synaptic inp...
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β...
Application of methods for detecting GH doping depend on being able to discriminate between abnormal levels due to doping and normal physiological levels of circulating proteins that change in response to exogenous admin...
New bone alliance seeks to strengthen knowledge and drive positive change

Biosensor mouse lights up health and disease

MEDIA RELEASE: Oct 06, 2017 05:00 AM
Garvan researchers have developed a biosensor mouse that gives a real-time readout of the rapidly changing ‘skeleton’ within cells. The researchers have watched cells respond dynamically to their surrounding environm...

A trigger that likely unleashes autoimmune disease

MEDIA RELEASE: May 13, 2015 05:30 AM
Australian researchers believe they have discovered a group of cells that trigger autoimmune disease, as well as the molecular ‘trigger guard’ that normally holds them in check. These previously undetected cells are ...
In a letter to the New England Journal of Medicine, published online today, endocrinologists from Garvan applauded a study in the October 11 issue showing a direct correlation between consumption of sugary soft drinks, o...

Keep an eye on your ears

MEDIA RELEASE: Apr 01, 2016 08:47 AM
Neglecting your hearing will decrease quality of life.

Improved rationale for attacking colorectal cancer

MEDIA RELEASE: Jan 17, 2011 06:20 PM
Some people respond very well to chemotherapy or radiotherapy for colorectal cancer, while others hardly respond at all – a fact that has been a bit of a mystery until now. A team of Garvan scientists believes the outc...
Researchers in Garvan’s Immunology Division are uncovering how the immune system’s ‘memory B cells’ give us long-term immunity to disease.
Garvan researchers are thrilled to be among the recipients of grants in recently announced funding schemes from the National Breast Cancer Foundation and Cancer Australia. The funding will provide crucial support for a n...

An enzyme that enables the pathway to diabetes

MEDIA RELEASE: Jun 29, 2015 06:00 AM
Garvan scientists believe they have identified an enzyme that undermines a delicately balanced whole-body system that keeps blood sugar levels stable and low in healthy people. The collapse of this system in the pancreas...
UK and Australian scientists have been able to show ways in which we can markedly improve drug targeting of solid tumours, using tiny ‘biosensors’ along with new advanced imaging techniques.
Insulin resistance is considered one of the earliest features of many metabolic diseases like Type 2 diabetes, and major efforts are aimed at improving insulin function to combat this problem. A Garvan research team prov...