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OBJECTIVE: ATL1103 is a second-generation antisense oligomer targeting the human growth hormone (GH) receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment fo...
Excess caloric intake results in increased fat accumulation and an increase in energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here ...

Neuroendocrinology group

Dec 04, 2013 05:38 PM
Evidence is accumulating of the clinical utility of single nucleotide polymorphisms to effectively stratify risk of breast cancer. Yet for this personalized polygenic information to be translated to clinical practice, co...
Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures. Four independent loci have been impl...
BACKGROUND: Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110delta subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K-AKT-mechanistic target of rapamycin pat...
Autoimmune cytopenias (AIC) following allogeneic hematopoietic stem cell transplantation (HSCT) may cause significant morbidity and mortality and are often challenging to treat. We present a case of a pediatric patient w...
MOTIVATION: Advanced high-throughput sequencing technologies have produced massive amount of reads data, and algorithms have been specially designed to contract the size of these datasets for efficient storage and transm...
The loss of functional beta cell mass characterises all forms of diabetes. Beta cells are highly susceptible to stress, including cytokine, endoplasmic reticulum (ER) and oxidative stress. This study examined the role of...
A Garvan-developed platform is providing researchers access to genomic data that will help drive discoveries in severe mitochondrial and brain disorders.
When a sperm and egg combine during fertilisation, they form a single cell that contains a person's full set of DNA
New findings from Australian and American researchers raise hope of living with advanced breast cancer – instead of dying from it.
BACKGROUND: Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technol...
The Garvan Institute of Medical Research considers that My Health Record will enhance patient care and help transform medical research.
Australian researchers identify a promising potential treatment for breast cancer – which targets non-cancerous cells within breast tumours, instead of the cancer itself