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Increased proliferation and altered growth factor dependence...
May 08, 2013 12:46 PM
The docking protein Gab2 is a proto-oncogene product that is overexpressed in primary breast cancers. To determine the functional consequences of Gab2 overexpression, we utilized the immortalized human mammary epithelial...
Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Ba...
May 08, 2013 12:46 PM
Autoimmune regulator (AIRE) is an important transcription regulator that mediates a role in central tolerance via promoting the ""promiscuous"" expression of tissue-specific Ags in the thymus. Although several mouse mode...
Regulation of B-Cell Self-Tolerance By BAFF and the Molecula...
May 08, 2013 12:46 PM
Signals delivered following the binding of BAFF to its receptor BAFF-R are essential for the survival of mature conventional B cells. In order to maintain self-tolerance, B cells that express antigen receptors with signi...
Not all dietary fats may lead to obesity
May 08, 2013 12:44 PM
Prognosis of fracture: evaluation of predictive accuracy of ...
May 08, 2013 12:46 PM
We evaluated the prognostic accuracy of fracture risk assessment tool (FRAX) and Garvan algorithms in an independent Australian cohort. The results suggest comparable performance in women but relatively poor fracture ris...
KAL1 is implicated in 5% of Kallmann syndrome cases, a disorder which genotypically overlaps with septo-optic dysplasia (SOD). To date, a reporter-based assay to assess the functional consequences of KAL1 mutations is la...
Hypothalamic regulation of cortical bone mass: opposing acti...
May 08, 2013 12:46 PM
NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed in cortical bone. Cortical bone mass is elevated in Y2(-/-) mice through greater ost...
5alpha-Reductase type 2 gene variant associations with prost...
May 08, 2013 12:46 PM
Controversy exists over the significance of associations between the SRD5A2 (5alpha-reductase type 2) polymorphisms, A49T and V89L, and risk of prostate cancer. These potentially functional polymorphisms may alter life-l...
Regulation of naive T cell function by the NF-kappaB2 pathwa...
May 08, 2013 12:45 PM
T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB ...
Incidence of diabetes mellitus in adult patients on growth h...
May 08, 2013 12:46 PM
Context: GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM). Objective: Our objective was to assess DM prevalence...
Bad news for beta-cell apoptosis
May 08, 2013 12:46 PM
The effects of Chinese medicinal herbs on postmenopausal vas...
May 08, 2013 12:45 PM
Large-scale delineation of secreted protein biomarkers overe...
May 08, 2013 12:45 PM
Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and hormones. Increased levels...
CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88L265P ...
