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A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-preg...
The processes regulating glucose-stimulated insulin secretion (GSIS) and its modulation by incretins in pancreatic beta-cells are only partly understood. Here we investigate the involvement of beta-catenin in these proce...
Introduction The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to th...
Prolactin (PRL) is the primary lactogenic pituitary hormone that plays an essential role in many aspects of reproduction, from fertilization to mammary gland development and maternal behavior. PRL has also been reported ...
Valproate is now the most widely prescribed mood-stabilizing drug and is being used increasingly in the treatment of bipolar disorder. However, the mechanism of action for valproate remains unclear. Microarray analysis w...
The 20-kDa growth hormone (GH) is generated from alternative splicing of the primary transcript of full-length 22-kDa GH. We have studied the regulation of 20-kDa GH over a range of pathophysiological conditions and in r...
T cell-dependent B cell responses generate optimal antibodies to combat foreign antigens. Naive B cells responding to antigen undergo a complex series of differentiation events and cell fate decisions to provide long-liv...
PURPOSE: Overexpression of E2F-1 is associated with increased invasiveness in head and neck squamous cell carcinoma cell lines in vitro, but its significance in vivo is unknown. This study sought to determine the relatio...
The vitamin D endocrine system has clear beneficial effects on bone as demonstrated by prevention of rickets in children and by reducing the risk of osteomalacia or osteoporosis in adults or elderly subjects. Depending o...
SUMMARY: Epigenetics, the study of heritable somatic phenotypic changes not related to DNA sequence, has emerged as a critical component of the landscape of gene regulation. The epigenetic layers, such as DNA methylation...
Nonalcoholic steatohepatitis (NASH) is a disorder characterized by hepatic steatosis, inflammation, and fibrosis. Leptin is an adipocyte-derived antiobesity hormone that in rodents prevents ""lipotoxicity"" by limiting t...
It has been more than a decade since it was recognised that the nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-?B) transcription factor family was activated by two distinct pathways: the canonical...
1. Evidence gathered in the last few years has revealed microRNAs (miRNAs) fine-tune gene expression and play an instrumental role in various cellular processes including cell growth, differentiation, proliferation and a...
Tumor heterogeneity has been identified at various -omic levels. The tumor genome, transcriptome, proteome, and phenome can vary widely across cells in patient tumors and are influenced by tumor cell interactions with he...