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Type 2 diabetes (T2D) is a metabolic disorder characterised by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. Pancreatic beta-cells secrete insulin in a biphasic manner, first and ...
Environmental enrichment (EE) refers to the provision of a complex and stimulating housing condition which improves well-being, behaviour and brain function of laboratory animals. The mechanisms behind these beneficial e...
CONTEXT AND OBJECTIVE: It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men...
OBJECTIVE: The aim of this study was to define the best available option for video capture of surgical procedures for educational and archival purposes, with a view to identifying methods of capturing high-quality footag...
Current views on how CD4+ T cells respond to antigen are based largely on highly artificial systems. A highly sensitive approach that allows normal T cell responses to be followed under physiological conditions overturns...
Cardiovascular disease is highly prevalent in chronic kidney disease (CKD) and is often associated with increased vascular stiffness and calcification. Recent studies have suggested a complex interaction between vascular...
Patients with fractures have reduced life expectancy (1-3). This is easily understood when death occurs following a hip fracture in an elderly frail individual (4). However, reduced life expectancy is also independently ...
Hypothalamic neuropeptide Y (NPY) has been implicated in the regulation of energy balance and reproduction, and chronically elevated NPY levels in the hypothalamus are associated with obesity and reduced reproductive fun...
T follicular helper (T(FH)) cells are a specialized subset of CD4(+) T cells that localize to B-cell follicles, where they are positioned to provide help for the induction of optimal humoral immune responses. Key feature...
The absence of a distinct clinical syndrome calls for a strategy to reliably identify patients with hyposomatotropism. However, there is no consensus as to the most appropriate method of defining growth hormone (GH) defi...
Four-day food records, body mass index and glycosylated hemoglobin levels were measured in 212 subjects with established non-insulin-dependent diabetes, who volunteered for a trial of educational programmes. Of these sub...
Three Garvan scientists will be taking their research on breast, prostate and pancreatic cancer to new heights, thanks to funding from Cancer Council NSW.
Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the de...
MOTIVATION: Comparing transcriptomic data with proteomic data to identify protein-coding sequences is a long-standing challenge in molecular biology, one that is exacerbated by the increasing size of high-throughput data...