Site Search
PKC alpha is activated but not required during glucose-induc...
May 08, 2013 12:45 PM
The role of protein kinase C (PKC) in glucose-stimulated insulin secretion (GSIS) is controversial. Using recombinant adenoviruses for overexpression of PKC alpha and PKC delta, in both wild-type (WT) and kinase-dead (KD...
Parkinson's disease
Jul 14, 2008 07:00 PM
Read about Parkinson's, symptoms and real life stories. Garvan's research focuses on early diagnosis, stopping progression with neuroprotective drugs, and clinical trials.
Brown adipose tissue (BAT), largely controlled by the sympathetic nervous system (SNS), has the ability to dissipate energy in the form of heat through the actions of uncoupling protein-1 (UCP-1),
thereby critically infl...
BACKGROUND & AIMS: Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) and its partners hypoxia-inducible factors (HIF)-1alpha and HIF-2alpha are candidate factors for the well-known link between the liver, metabolic d...
KDIGO clinical practice guideline for the diagnosis, evaluat...
May 08, 2013 12:46 PM
Disorders in mineral metabolism and bone disease are common complications of chronic kidney disease (CKD), and a significant cause of the morbidity and decreased quality of life of CKD patients. Importantly, there is an ...
Growth hormone measurements in the diagnosis and monitoring ...
May 08, 2013 12:46 PM
Before the availability of immunoassays for IGF-I, growth hormone (GH) measurement was the sole method used in the biochemical assessment of acromegaly. IGF-I has since been established as the most reliable biochemical i...
Increasing incidence of type 2 diabetes in the third millenn...
May 08, 2013 12:45 PM
BACKGROUND: The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation of the malaria parasite, since only mature gametocytes will survive in the mosquito'...
Comparison of the metabolic effects of raloxifene and oral e...
May 08, 2013 12:45 PM
CONTEXT: The endocrine and metabolic functions of the liver are affected by estrogen. Oral estrogen reduces IGF-I and suppresses fat oxidation despite augmenting GH secretion. The aim of this study was to determine wheth...
BACKGROUND: A fracture liaison service model of care is widely recommended and applied, but data on its effectiveness are scarce. Therefore, the risk of subsequent nonvertebral fractures and mortality within two years af...
Moderate alcohol consumption, dietary fat composition, and a...
May 08, 2013 12:45 PM
We examined relationships among alcohol intake, dietary fat composition, and total body fat (TBF) and central abdominal fat (CAF), independent of genetic confounders, and evaluated the modulating effect of genetic suscep...
A major weakness in many high-throughput genomic studies is the lack of consideration of a clinical environment where one patient at a time must be evaluated. We examined generalizable and platform-specific sources of va...
Skills acquired on virtual reality laparoscopic simulators t...
May 08, 2013 12:45 PM
Virtual reality surgical simulators have proven value in the acquisition and assessment of laparoscopic skills. In this study, we investigated skill transfer from a virtual reality laparoscopic simulator into the operati...
Steroid radioimmunoassay--effect of shortened incubation tim...
May 08, 2013 12:44 PM
Use of a briefer incubation interval in several steroid radioimmunoassays markedly increases cross reactions with some closely related steroids. The dissociation rates of the various steroid/antibody complexes play a cri...
Human islets express a marked pro-inflammatory molecular sig...
May 08, 2013 12:46 PM
In the context of islet transplantation, experimental models show that induction of islet intrinsic NF-kappaB-dependent pro-inflammatory genes can contribute to islet graft rejection. Isolation of human islets triggers a...
