Site Search
Suggestive linkage of the parathyroid receptor type 1 to ost...
May 08, 2013 12:45 PM
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by linkage studies in families of probands with osteoporosis (lumbar spine [LS] or femoral neck [FN] BMD T score < -2.5) an...
PYY transgenic mice are protected against diet-induced and g...
May 08, 2013 12:46 PM
The gut-derived hormone, peptide YY (PYY) reduces food intake and enhances satiety in both humans and animals. Obese individuals also have a deficiency in circulating peptide YY, although whether this is a cause or a con...
The role of brain noradrenaline in the neural control of glu...
May 08, 2013 12:44 PM
Mechanisms of 5-hydroxy-L-tryptophan-induced adrenocorticotr...
May 08, 2013 12:44 PM
The serotonin (5-hydroxytryptamine, 5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP) and 5-HT antagonists, respectively, are able to stimulate and block pituitary adrenocorticotropin (ACTH) release. However, our previous d...
PURPOSE: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse.<br /><br />Experimental Design: We studied responses to various mono- and b...
Based on the consistent demonstration of fibrosis of the atrioventricular node surrounded by macrophages and multinucleated giant cells in anti-Ro antibody exposed fetuses dying with heart block, this study focuses on ma...
Growth hormone in sports: detecting the doped or duped
May 08, 2013 12:46 PM
BACKGROUND: Doping with growth hormone (GH) is banned; however, there is anecdotal evidence that it is widely abused. GH is reportedly often used in combination with anabolic steroids at high doses for several months. De...
Relating structure to function in the beta-propeller domain ...
May 08, 2013 12:45 PM
Point mutations in human CD26/DP IV were analysed for adenosine deaminase (ADA) binding, monoclonal antibody (mAb) binding and DP IV enzyme activity. Point mutations at either Leu294 or Val341 ablated ADA binding. Bindin...
The cytokine IL-21 has been shown to influence immune responses through both costimulatory effects on effector T cells and opposing inhibitory effects on T regulatory cells (Tregs). To distinguish the effect of IL-21 on ...
Hormonal responses to fenfluramine in depressive subtypes
May 08, 2013 12:44 PM
In order to study putative differences in central neurotransmitter function in depressive subtypes, serum cortisol and prolactin responses to the putative serotonin agonist fenfluramine were examined in 30 subjects with ...
The second galanin receptor GalR2 plays a key role in neurit...
May 08, 2013 12:45 PM
Expression of the neuropeptide galanin is markedly upregulated within the adult dorsal root ganglion (DRG) after peripheral nerve injury. We demonstrated previously that the rate of peripheral nerve regeneration is reduc...
The postprandial response of adiponectin to a high-fat meal ...
May 08, 2013 12:45 PM
OBJECTIVE: Adiponectin is an adipose-specific protein with short-term effects in vivo on glucose and fatty acid levels. We studied the plasma concentration and the proteolytic activation status of adiponectin following t...
It is well established that cancer-associated epigenetic repression occurs concomitant with CpG island hypermethylation and loss of nucleosomes at promoters, but the role of nucleosome occupancy and epigenetic reprogramm...
Radioimmunoassay of cholecystokinin in human plasma
May 08, 2013 12:44 PM
A sensitive radioimmunoassay for cholecystokinin (CCK) has been developed. Porcine CCK-33 was labelled by conjugation with 125I-hydroxyphenyl-propionic acid succinimide ester. Antibodies were raised against porcine CCK-3...
