Insight into the dazzling impact of insulin in cells
MEDIA RELEASE: 21 May 2013Garvan scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes. The breakthrough study is now published in the early online edition of the prestigious journal Cell Metabolism.
Garvan and St Vincent’s Welcome Critical Prostate Cancer Funding for The Kinghorn Cancer Centre
MEDIA RELEASE: 17 May 2013Both the Garvan Institute of Medical Research and St Vincent’s Hospital have welcomed the Federal Government’s foreshadowed announcement in this week’s budget of $5.5 million over 4 years to The Kinghorn Cancer Centre’s National Prostate Cancer Research Centre.
Garvan and Cancer Therapeutics CRC Pty Ltd License Pan-Kinase Binding Agent to SYNkinase
MEDIA RELEASE: 16 May 2013Garvan and Cancer Therapeutics CRC Pty Ltd have signed a licence agreement with SYNkinase Pty Ltd to develop and market a unique Pan-Kinase Binding Agent to help screen human cells and tissues and identify potential drug targets in diseased states. The novel agent has the unique ability to detect a large proportion of the protein kinase family, giving it the potential to become a remarkable research tool for life scientists around the globe.
Evidence that brains re-wire themselves following damage or injury
MEDIA RELEASE: 14 May 2013Neuroscientists from Garvan, in collaboration with learning theorists from the University of California Los Angeles (UCLA), have advanced our understanding of brain plasticity by showing that the brain forms complex new circuits after damage, often far from the damaged site, to compensate for lost function. This is the first demonstration of such circuit plasticity.
John Schubert becomes Chairman of Garvan
MEDIA RELEASE: 01 May 2013The Garvan Institute of Medical Research is delighted to announce the appointment this week of Dr John Schubert AO to its Board by the Governor of New South Wales, Her Excellency Professor Marie Bashir AC CVO, and his subsequent election by the Board as its Chair. He succeeds Mr Bill Ferris AC, Garvan Chairman since 2001.
The connection between faulty neural activation and schizophrenia
MEDIA RELEASE: 28 Apr 2013By studying what happens in the normal brain when neurons fire, Australian scientists have been able to identify a finely and dynamically regulated process. They also describe how dysfunction of this process is associated with schizophrenia. The process involves a specific class of genes known as ‘long non-coding RNAs’.
Obesity may explain reduced bone fracture worldwide
MEDIA RELEASE: 10 Apr 2013A Garvan study shows that women – but not men – with more abdominal fat are less at risk of bone fracture. This may explain why global rates of fracture are declining at the same time as obesity is increasing. The data come from the ongoing Dubbo Osteoporosis Epidemiology Study (DOES).
Forget about plaque when diagnosing Alzheimer’s Disease
MEDIA RELEASE: 02 Apr 2013A Garvan study has shown that plaque, long considered to be the hallmark of Alzheimer’s disease, is one of the last events to occur in the Alzheimer’s brain. This finding will impact the current debate about how best to diagnose and treat Alzheimer’s disease.
How the immune system positions its gatekeepers
MEDIA RELEASE: 18 Mar 2013For an immune response to get underway, an invading microbe must first be halted in the spleen, and then digested by immune cells known as ‘dendritic cells’, which guard specific portals. Garvan scientists have now shown how these gatekeepers position themselves to undertake their task. The findings are now published online today in the prestigious journal Nature Immunology.
NSW lifestyle medicine program for severe mental illness adapted for use in UK
MEDIA RELEASE: 19 Feb 2013A lifestyle medicine program designed in New South Wales to combat the dramatic weight gain and metabolic decline associated with anti-psychotic drug use, has recently been adapted in the United Kingdom. It has been offered as an implementation resource to accompany the UK’s National Institute for Health and Clinical Excellence (NICE) guidelines for management of children and young people with psychosis.
The brain circuit that makes it hard for obese people to lose weight
MEDIA RELEASE: 06 Feb 2013When people diet, they often find it virtually impossible to lose weight - the less food they eat, the less energy they burn, and the less weight they lose. Garvan scientists explain the exact brain circuitry behind this phenomenon.
A step towards better understanding of pancreatic cancer
MEDIA RELEASE: 04 Feb 2013Garvan scientists, along with collaborators from Belgium and Spain, have observed that the well-studied protein Sirtuin-1, known for helping cells live longer, also appears to play an important role in the initiation and development of pancreatic cancer. They believe that inhibiting Sirtuin-1 may help prevent the initiation of pancreatic cancer, as well as prevent the further growth of established tumours.
Cellular garbage may explain effects of insulin resistance and diabetes
MEDIA RELEASE: 31 Jan 2013Insulin resistance is considered one of the earliest features of many metabolic diseases like Type 2 diabetes, and major efforts are aimed at improving insulin function to combat this problem. A Garvan research team provides evidence that elevated insulin levels caused by insulin resistance may play a large role in illness by shutting off a natural cellular garbage disposal system. Their finding begs a re-evaluation of treatment strategies.
Measuring distress in people with Types 1 and 2 diabetes
MEDIA RELEASE: 21 Jan 2013Diabetes experts, psychiatrists and neuroscientists have reported the benefits of measuring depression and disease-related distress in patients with diabetes. They have also shown that distress is influenced by heritable genetic changes in the way patients’ bodies handle serotonin, a neurotransmitter that regulates mood.
The genes that drive soft drink consumption and weight gain
MEDIA RELEASE: 17 Jan 2013In a letter to the New England Journal of Medicine, published online today, endocrinologists from Garvan applauded a study in the October 11 issue showing a direct correlation between consumption of sugary soft drinks, obesity and genetic predisposition to weight gain. They wrote to underline the degree to which appetite is genetically determined rather than being solely a lifestyle choice. They also appealed to policy makers to understand the science behind obesity, and protect those ‘at risk’.