Lab Head - Cancer Cell Plasticity
Christine completed her training in cancer biology at the University of Melbourne (PhD) followed by her post-doctoral studies at the Whitehead Institute of Biomedical Research, MIT, Cambridge, USA, with Professor Robert A Weinberg - a world-leader in cancer biology. Her passion and career focus is understanding the mechanisms driving human cancer development, progression and metastasis. Her work also aims to provide translational therapeutic benefits. Christine has challenged, and changed, pre‐established paradigms in cancer biology, and she has multiple high-impact papers demonstrating the effects of cancer cell plasticity on driving tumour progression and development into metastatic disease. Her strengths include mammary gland biology, breast cancer biology, cancer stem cells/tumour-initiating cells and cellular transitions, including the epithelial‐to‐mesenchymal (EMT) and the reverse process, the mesenchymal‐to‐epithelial (MET) transition. In her laboratory, Christine will continue to focus on cellular plasticity, and the ability of cells to switch phenotypes as a mode of acquiring enhanced tumourigenicity and metastatic ability.