Dr Daniel Suan

Research Officer - Immunogenomics Lab

Dr Daniel Suan

Dan grew up in Perth and studied medicine at UWA before moving to Sydney to train as an Immunologist at Westmead Hospital and St Vincent's Hospital. After this, he completed his PhD in 2015 in the lab of Professor Rob Brink at Garvan, using transgenic mouse models to investigate memory B cell and pl

Biography

Dan grew up in Perth and studied medicine at UWA before moving to Sydney to train as an Immunologist at Westmead Hospital and St Vincent's Hospital. After this, he completed his PhD in 2015 in the lab of Professor Rob Brink at Garvan, using transgenic mouse models to investigate memory B cell and plasma cell differentiation in the germinal centre response, the mechanism by which the human immune system forms antibodies and long-lived memory against infection and vaccination.

Dan was appointed as a Staff Specialist in Clinical Immunology and Immunopathology at Westmead Hospital in 2015, where he cares for patients with a wide range of immune conditions, including autoimmune diseases, allergies, immunodeficiencies and HIV infection. Dan has a longstanding interest and commitment to teaching and training, and is a Conjoint Senior Lecturer at both the University of Sydney and UNSW. He remained part-time at Garvan to continue his research training and establish a genomics program to study the cause of human autoimmune disorders under the supervision of Professor Chris Goodnow.

The ambitious Hope Research program is studying over 40 autoimmune diseases, including CREST syndrome, psoriatic arthritis, lupus, Sjogren's syndrome, multiple sclerosis and inclusion body myositis, utilising the latest single-cell sequencing technologies. Dan’s research has been supported by funding from the NHMRC, UNSW Triple I, Multiple Sclerosis Research Australia and by generous philanthropic donations and support from community bodies.

Dan grew up in Perth and studied medicine at UWA before moving to Sydney to train as an Immunologist at Westmead Hospital and St Vincent's Hospital. After this, he completed his PhD in 2015 in the lab of Professor Rob Brink at Garvan, using transgenic mouse models to investigate memory B cell and plasma cell differentiation in the germinal centre response, the mechanism by which the human immune system forms antibodies and long-lived memory against infection and vaccination.

Dan was appointed as a Staff Specialist in Clinical Immunology and Immunopathology at Westmead Hospital in 2015, where he cares for patients with a wide range of immune conditions, including autoimmune diseases, allergies, immunodeficiencies and HIV infection. Dan has a longstanding interest and commitment to teaching and training, and is a Conjoint Senior Lecturer at both the University of Sydney and UNSW. He remained part-time at Garvan to continue his research training and establish a genomics program to study the cause of human autoimmune disorders under the supervision of Professor Chris Goodnow.

The ambitious Hope Research program is studying over 40 autoimmune diseases, including CREST syndrome, psoriatic arthritis, lupus, Sjogren's syndrome, multiple sclerosis and inclusion body myositis, utilising the latest single-cell sequencing technologies. Dan’s research has been supported by funding from the NHMRC, UNSW Triple I, Multiple Sclerosis Research Australia and by generous philanthropic donations and support from community bodies.

Selected Publications

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody. 
Singh M, Jackson KJL, Wang JJ, Schofield P, Field MA, Koppstein D, Peters TJ, Burnett DL, Rizzetto S, Nevoltris D, Masle-Farquhar E, Faulks ML, Russell A, Gokal D, Hanioka A, Horikawa K, Colella AD, Chataway TK, Blackburn J, Mercer TR, Langley DB, Goodall DM, Jefferis R, Gangadharan Komala M, Kelleher AD, Suan D, Rischmueller M, Christ D, Brink R, Luciani F, Gordon TP, Goodnow CC, Reed JH. Cell. 2020 Mar 5;180(5):878-894.e19. doi: 10.1016/j.cell.2020.01.029. Epub 2020 Feb 13.

Coronary artery vasospasm in a patient with Churg-Strauss syndrome.
Trivedi SJ, Tanous D, Suan D
BMJ Case Rep. 2018 Oct 25;2018. pii: bcr-2018-225321. doi: 10.1136/bcr-2018-225321.

Gastric Cancer Screening in Common Variable Immunodeficiency. 
van der Poorten DK, McLeod D, Ahlenstiel G, Read S, Kwok A, Santhakumar C, Bassan M, Culican S, Campbell D, Wong SWJ, Evans L, Jideh B, Kane A, Katelaris CH, Keat K, Ko Y, Lee JA, Limaye S, Lin MW, Murad A, Rafferty M, Suan D, Swaminathan S, Riminton SD, Toong C, Berglund LJ. 
J Clin Immunol. 2018 Oct;38(7):768-777. doi: 10.1007/s10875-018-0546-3. Epub 2018 Sep 15.

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity. 
Suan D, Kräutler NJ, Maag JLV, Butt D, Bourne K, Hermes JR, Avery DT, Young C, Statham A, Elliott M, Dinger ME, Basten A, Tangye SG, Brink R. 
Immunity. 2017 Dec 19;47(6):1142-1153.e4. doi: 10.1016/j.immuni.2017.11.022. 

A novel cause of chronic viral meningoencephalitis: Cache Valley virus. 
Wilson MR, Suan D, Duggins A, Schubert RD, Khan LM, Sample HA, Zorn KC, Rodrigues Hoffman A, Blick A, Shingde M, DeRisi JL. 
Ann Neurol. 2017 Jul;82(1):105-114. doi: 10.1002/ana.24982.