David Murray

Scientific Officer

David Murray

David is the Scientific Officer at the Kinghorn Centre for Clinical Genomics, working to support a number of projects across the centre. He has an industry background and spent many years working in the pharmaceutical industry developing methods to support drug development and manufacturing of monoc

Biography

David is the Scientific Officer at the Kinghorn Centre for Clinical Genomics, working to support a number of projects across the centre. He has an industry background and spent many years working in the pharmaceutical industry developing methods to support drug development and manufacturing of monoclonal antibody therapeutics. Prior to joining KCCG, he developed a liquid biopsy for colorectal cancer at Clinical Genomics in collaboration with CSIRO. This test is currently available through a CLIA laboratory in the US.

David is the Scientific Officer at the Kinghorn Centre for Clinical Genomics, working to support a number of projects across the centre. He has an industry background and spent many years working in the pharmaceutical industry developing methods to support drug development and manufacturing of monoclonal antibody therapeutics. Prior to joining KCCG, he developed a liquid biopsy for colorectal cancer at Clinical Genomics in collaboration with CSIRO. This test is currently available through a CLIA laboratory in the US.

Education

2017 – MSc Biostatistics, Sydney University
2004 - BSc Biotechnology, Dublin City University

Selected Publications

  • Erin L Symonds, Susanne K Pedersen, David Murray, Susan E Byrne, Amitesh Roy, Christos Karapetis, Paul Hollington, Philippa Rabbitt, Frederick S. Jones, Lawrence LaPointe, Eva Segelov, Graeme P Young. Circulating epigenetic biomarkers for detection of recurrent colorectal cancer. Cancer. 2020;126(7):1460-1469. doi:10.1002/cncr.32695
  • David H Murray, Erin L Symonds, Graeme P Young, Susan Byrne, Philippa Rabbitt, Amitesh Roy , Kathryn Cornthwaite, Christos S Karapetis, Susanne K Pedersen. Relationship between post-surgery detection of methylated circulating tumor DNA with risk of residual disease and recurrence-free survival. Journal of Cancer Research and Clinical Oncology. 2018.
  • Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin, Graeme P. Young. Circulating tumour DNA for monitoring colorectal cancer– a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection. Clinical Epigenetics. 2018; 10:63.
  • David H. Murray, Rohan T. Baker, Snigdha Gaur, Graeme P. Young, Susanne K. Pedersen. Validation of a Circulating Tumor-Derived DNA Blood Test for Detection of Methylated BCAT1 and IKZF1 DNA. Journal of Applied Laboratory medicine. 2017; 2:165–75.
  • Graeme P. Young, Susanne K. Pedersen, Scott Mansfield, David H. Murray, Rohan T. Baker, Philippa Rabbitt, Susan Byrne, Libby Bambacas, Paul Hollington, Erin L. Symonds. A Cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumour-derived DNA with CEA for detection of recurrent colorectal cancer. Cancer Medicine. 2016; 5:2763–72.
  • Erin L. Symonds, Susanne K. Pedersen, Rohan T. Baker, David H. Murray, Snigdha Gaur, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Graeme P. Young. A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia. Clinical and Translational Gastroenterology. 2016;7(1):e137-. doi:10.1038/ctg.2015.67.
  • Susanne K. Pedersen, Erin L. Symonds, Rohan T. Baker, David H. Murray, Aidan McEvoy, Sascha C. Van Doorn, Marco W. Mundt, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Evelien Dekker, Graeme P. Young. Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia. BMC Cancer. 2015;15:654.
  • Susanne K. Pedersen, Rohan T. Baker, Aidan McEvoy, David H. Murray, Melissa Thomas, Peter L. Molloy, Sue Mitchell, Trevor Lockett, Graeme P. Young, Lawrence C. LaPointe. A Two-Gene Blood Test for Methylated DNA Sensitive for Colorectal Cancer. PLoS ONE 10(4). 2015;10:e0125041.