Katherine Jackson

Katherine’s research focuses on the application of immune receptor repertoire sequencing methodologies to study both immune responses to vaccination and infection and to study the genetics of the immune gene loci, with an interest in the role of individual immunogenetic variability and its impact on
Senior Research Officer

Katherine’s research focuses on the application of immune receptor repertoire sequencing methodologies to study both immune responses to vaccination and infection and to study the genetics of the immune gene loci, with an interest in the role of individual immunogenetic variability and its impact on the development of antibody repertoires and immune responses. Katherine completed her PhD at the University of New South Wales investigating the inference of antigen selection from immunoglobulin heavy chain sequence data.

Following her PhD, Katherine has undertaken post-doctoral training at the University of New South Wales and Stanford University. During these roles she adapted methods developed during her doctoral studies to the larger immune receptor datasets that result from next generation sequencing platforms, and applied these to the monitoring B cell responses in vaccination and infection.

Katherine’s current research continues to focus on utilising immune receptor repertoire sequencing to understand the evolution of responses in contexts ranging from primary vaccination (eg. Rabies vaccination) and infection (eg. Ebola virus, acute EBV), to secondary vaccination (eg. seasonal influenza vaccination) and circumstances of autoimmunity or immune dysregulation.

Research Interests

Humoral immunity
Immune repertoire sequencing
Immuno-informatics
Vaccine responses
Immunogenetics

Awards and Honours

2016 - Best Scientific Poster Prize (Stanford Pathology Retreat)
2014 - Paper of the Month (BABS UNSW)
2013 - ICI 2013 Bursaries to Young Immunologists
2007 - ASI Travel Award
2004-2007 - Australian Postgraduate Award
2004 - The Baldwin Shelston Waters Prize for best performance in Professional Issues in Biotech
2003 - The Beckman Coulter prize for best performance in Honours in Bachelor of Science
2003 - Faculty of Science Award for best performance in honours

Education

2008 - PhD, University of New South Wales - Australia
2004 - Diploma of Innovation Management, University of New South Wales - Australia
2003 - BSc (Hons), University of New South Wales - Australia

Selected Publications

Ellebedy A.H., Jackson K.J.L., Kissick H.T., Nakaya H.I., Davis C.W., Roskin K.M., McElroy A.K., Oshansky C.M., Elbein R., Thomas S., Lyon G.M., Spiropoulou C.F., Mehta A.K., Thomas P.G., Boyd S.D., Ahmed R. (2016). Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nature Immunology 17, 1226-1234

Scheepers C., Shrestha R.K., Lambson B.E., Jackson K.J.L., Wright I.A., Naicker D., Goosen M., Berrie L., Ismail A., Garrett N., Abdool Karim Q., Abdool Karim S.S., Moore P.L., Travers S.A., Morris L. (2015). Ability to develop broadly neutralizing HIV-1 Antibodies is not restricted by the germline Ig gene repertoire. The Journal of Immunology 194(9), 4371-4378

Jackson K.J.L., Li Y., Roskin K.M., Glanville J., Hoh R.A., Seo K., Marshall E.L., Gurley T.C., Moody M.A., Haynes B.F., Walter E.B., Liao H-X., Albrecht R.A., Garcia-Sastre A., Chaparro-Riggers J., Rajpal A., Pons J., Simen B.B., Hanczaruk B., Dekker C.L., Laserson J., Koller D., Davis M.M., Fire A.Z., Boyd S.D. (2014) Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host & Microbe 16(1), 105-114

Jackson K.J.L., Wang Y., Collins A.M. (2014) Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels. Immunology and Cell Biology 92(8), 729-733

Trama A.M., Moody M.A., Alam S.M., Jaeger F.H., Lockwood B., Parks R., Lloyd K.E., Stolarchuk C., Scearce R., Foulger A., Marshall D.J., Whitesides J.F., Jeffries T.L., Wiehe K., Morris L., Lambson B., Soderberg K., Hwang K-K., Tomaras G.D., Vandergrift N., Jackson K.J.L., Roskin K.M., Boyd S.D., Kepler T.B., Liao H-X., Haynes B.F. (2014) HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host & Microbe 16(2), 215-226 

Wang Y., Jackson K.J.L., Davies J., Chen Z., Gaeta B.A., Rimmer J., Sewell W.A., Collins A.M. (2014) IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection. PLoS One 9(2), e89730

Wang C., Liu Y., Xu L.T., Jackson K.J.L., Roskin K.M., Pham T.D., Laserson J., Marshall E.L., Seo K., Lee J-Y., Furman D., Koller D., Dekker C.L., Davis M.M., Fire A.Z., Boyd S.D. (2014) Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires. Journal of Immunology 192(2), 603-611

Parameswaran P., Liu Y., Roskin K.M., Jackson K., Dixit V.P., Lee J-Y., Artiles K.L., Zompi S., José Vargas M., Simen B.B., Hanczaruk B., McGowan K.R., Tariq M.A., Pourmand N., Koller D., Balmaseda A., Boyd S.D., Harris E., Fire A.Z. (2013) Convergent antibody signatures in human Dengue. Cell Host & Microbe 13(6), 691-700

Jackson K.J.L., Wang Y., Gaeta B.A., Pomat W., Siba P., Rimmer J., Sewell W.A., Collins A.M. (2012) Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells. Immunogenetics 64(1), 3-14

Wang Y., Jackson K.J., Gäeta B., Pomat W., Siba P., Sewell W.A., Collins A.M. (2011) Genomic screening by 454 pyrosequencing identifies a new human IGHV gene and sixteen other new IGHV allelic variants. Immunogenetics 63(5), 259-65

Boyd S.D., Gaëta B.A., Jackson K.J., Fire A.Z., Marshall E.L., Merker J.D., Maniar J.M., Zhang L.N., Sahaf B., Jones C.D., Simen B.B., Hanczaruk B., Nguyen K.D., Nadeau K.C., Egholm M., Miklos D.B., Zehnder J.L., Collins A.M. (2010) Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. Journal of Immunology 184(12), 6986-92

Jackson K.J., Gaëta B.A., Collins A.M. (2007) Identifying highly mutated IGHD genes in the junctions of rearranged human immunoglobulin heavy chain genes. Journal of Immunological Methods 324(1-2), 26-37

Gaëta B.A., Malming H.R., Jackson K.J., Bain M.E., Wilson P., Collins A.M. (2007) iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences. Bioinformatics 23(13), 1580-7

Jackson K.J., Gaeta B., Sewell W., Collins A.M. (2004) Exonuclease activity and P nucleotide addition in the generation of the expressed immunoglobulin repertoire. BMC Immunology 5 19

Person portrait

Katherine Jackson

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