Prof Peter Croucher

Research Director - Bone Biology

Prof Peter Croucher

Professor Peter Croucher graduated with a BSc in Zoology from University College Cardiff in 1987 and completed a PhD at the University of Wales, College of Medicine, Cardiff, in 1990. Peter’s postdoctoral training was in the Department of Medicine at the University of Cambridge and in the Department

Biography

Professor Peter Croucher graduated with a BSc in Zoology from University College Cardiff in 1987 and completed a PhD at the University of Wales, College of Medicine, Cardiff, in 1990. Peter’s postdoctoral training was in the Department of Medicine at the University of Cambridge and in the Department of Human Metabolism and Clinical Biochemistry, University of Sheffield. In 1997, Peter was awarded a prestigious five-year Bennett Senior Fellowship by the Leukaemia Research Fund.

He relocated to the University of Oxford, Institute of Musculoskeletal Sciences as a Senior Research Fellow in 2001 and then returned to the School of Medicine and Biomedical Sciences at the University of Sheffield in 2003 as Professor of Bone Biology. In 2009 he was appointed Head of the Department of Human Metabolism and Director of the Mellanby Centre for Bone Research. In 2011, Peter moved to the Garvan Institute of Medical Research where he is now Head of the Division of Bone Biology.  

Education

1991 - PhD, University of Wales - UK
1987 - BSc (Hons) Zoology, University College Cardiff - UK

Selected Publications

John P Kemp, John A Morris, Carolina Medina-Gomez5, Vincenzo Forgetta, Nicole M Warrington, Scott E Youlten, Jie Zheng, Celia L Gregson, Elin Grundberg, Katerina Trajanoska, John G Logan, Andrea S Pollard, Penny C Sparkes, Elena J Ghirardello, Rebecca Allen, Victoria D Leitch, Natalie C Butterfield, Davide Komla-Ebri, Anne-Tounsia Adoum, Katharine F Curry, Jacqueline K White, Fiona Kussy, Keelin M Greenlaw, Changjiang Xu, Nicholas C Harvey, Cyrus Cooper, David J Adams, Celia M T Greenwood, Matthew T Maurano, Stephen Kaptoge, Fernando Rivadeneira, Jonathan H Tobias, Peter I Croucher, Cheryl L Ackert-Bicknell, J H Duncan Bassett, Graham R Williams, J Brent Richards & David M Evans. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet. 2017 Sep 4. doi: 10.1038/ng.3949. Epub 2017 Sep 4.

John A Morris, John P Kemp, Scott E Youlten, Laetitia Laurent, John G Logan, Ryan Chai, Nicholas A Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu Mohanty, C Marcelo Sergio, Julian Quinn, Loan Nguyen-Yamamoto, Aimee-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, Albena Pramatarova, Carolina Medina-Gomez, Katerina Trajanoska, Elena J Ghirardello, Natalie C Butterfield, Katharine F Curry, Victoria D Leitch, Penny C Sparkes, Anne-Tounsia Adoum, Naila S Mannan, Davide Komla-Ebri, Andrea S Pollard, Hannah F Dewhurst, Thomas Hassell, Michael-John G Beltejar, Douglas J Adams, Suzanne M Vaillancourt, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Douglas P Kiel, Jonathan H Tobias, Celia L Gregson, Nicholas C Harvey, Elin Grundberg, David Goltzman, David J Adams, Christopher J Lelliott, David A Hinds, Cheryl L Ackert-Bicknell, Yi-Hsiang Hsu, Matthew T Maurano, Peter I Croucher,Graham R Williams, JH Duncan Bassett, David M Evans, J Brent Richards. An atlas of human and murine genetic influence on osteoporosis. Nat Genet. bioRxiv 338863; doi: https://doi.org/10.1101/338863.

McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. Inhibiting the osteocyte specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017 Jun 29;129(26):3452-3464. doi: 10.1182/blood-2017-03-773341. Epub 2017 May 17.

Croucher PI, McDonald MM, Martin TJ. Bone metastasis: the importance of the neighbourhood. (2016) Nat Rev Cancer. May 25;16(6):373-86.

Lawson MA, McDonald MM, Kovacic N, Hua Khoo W, Terry RL, Down J, Kaplan W, Paton-Hough J, Fellows C, Pettitt JA, Neil Dear T, Van Valckenborgh E, Baldock PA, Rogers MJ, Eaton CL, Vanderkerken K, Pettit AR, Quinn JM, Zannettino AC, Phan TG, Croucher PI. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. (2015) Nat Commun. Dec 3;6:8983.

Bassett, J.H.D., Gogakos, A., White, J.K., Evans, H., Jacques, R.M., Van der Spek, A., Sanger Mouse Genetics Project, Ramirez-Solis, R., Ryder, E., Sunter, D., Boyde, A., Campbell, M.J., Croucher, P.I., Williams, G.R. (2012) Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genetics. 8:e1002858.

Baud’huin, M., Nicolas Solban, N., Cornwall-Brady, M., Sako, D., Kawamoto, Y., Liharska, K., Lath, D., Bouxsein, M.L., Underwood, K.W., Ucran, J., Kumar, R., Pobre, E.G., Grinberg, A.V., Seehra, J., Canalis, E., Pearsall, R.S., Croucher, P.I. (2012) A Soluble Alk3/BMPR1A Receptor Increases Bone Mass and Bone Strength.  Proceedings of the National Academy of Sciences USA. 109:12207-12212.

Chantry, A.D., Heath, D., Mulivor, A., Pearsall, R.S., Baud’huin, M., Coulton, L., Evans, H., Abdul, N., Werner, E.D., Bouxsein,M.L., Key, M.L., Arnett, T.R., Seehra, J., Vanderkerken, K., Croucher, P.I. (2010) Inhibiting activin-A signaling stimulates bone formation and prevents cancer induced bone destruction in vivo. Journal of Bone and Mineral Research.  25:2357-2370.

Heath, D.J., Chantry, A.D., Buckle, C., Coulton, L., Shaughnessy Jr, J.D., Evans, H., Stover, D.R., Vanderkerken, K., Croucher, P.I. (2009) Inhibiting Dickkopf-1 (Dkk-1) prevents the development of osteolytic bone disease in multiple myeloma. Journal of Bone and Mineral Research, 24:425-436.

Heath, D.J., Vanderkerken, K., Cheng, X., Gallagher, O, Prideaux, M., Murali, R., Croucher, P.I. (2007). An Osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma. Cancer Research, 67:202-208.

Vitovski, S., Phillips, JS, Sayers, J, Croucher, P.I. (2007). Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways. Journal of Biological Chemistry, 282:31601-31609.

Vanderkerken, K., Medicherla, S., Coulton, L., De Raeve, H., Willems, A., Lawson, M., Van Camp, B., Protter, A.A., Higgins, L.S., Menu, E., Croucher, P.I. (2007). Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma. Cancer Research, 67:4572-4577.

Karadag, A., Zhou, M., Croucher, P.I. (2006) ADAM-9 (MDC-9/meltrin-g), A Member of the A Disintegrin and Metalloproteinase Family, Regulates Myeloma Cell Induced Interleukin-6 Production in Osteoblasts by Direct Interaction with the avb5-Integrin. Blood, 107:3271-3278. 

Croucher, P.I., De Raeve, H., Perry, M.J., Hijzen, A., Shipman, C.M., Lippitt, J., Green, J., Van Marck, E., Van Camp, B., Vanderkerken, K. (2003) Zoledronic acid prevents the development of osteolytic bone lesions and increases survival in the 5T2MM murine model of multiple myeloma. Journal of Bone and Mineral Research. 18:482-492.

Shipman, C.M., Croucher, P.I. (2003) Osteoprotegerin is a soluble decoy receptor for TRAIL/Apo2L and can inhibit TRAIL/Apo2L-induced apoptosis of human myeloma cells in vitro. Cancer Research. 63:912-916.

Vanderkerken, K., De Leenheer, E., Shipman, C.M., Asosingh, K., Willems, A., Van Camp, B., Croucher, P.I. (2003) Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Research. 63:287-289.

Holen, I., Croucher, P.I., Hamdy, F., Eaton, C.L. (2002) Osteoprotegerin (OPG) is a survival factor for human prostate cancer. Cancer Research, 62:1619-1623.

Croucher, P.I., Shipman, C.M., Lippitt, J., Perry, M., Asosingh, K., Hijzen, A., Brabbs, A.C., van Beek, E.J.R., Holen, I., Skerry, T.M., Dunstan, C.R., Russell, R.G.G. Russell, Van Camp, B., Vanderkerken, K. (2001) Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood, 98:3534-3540.