Dr Peter Schofield

Senior Research Officer - Antibody Therapeutics Lab

Dr Peter Schofield

I am an expert antibody engineer, collaborating with many research teams both locally and internationally to develop monoclonal antibodies as therapeutic lead candidates. I have also used in vitro antibody expression and binding kinetic analysis to answer fundamental questions about how B cells of t

Research Level

Senior Staff Scientist

Biography

I am an expert antibody engineer, collaborating with many research teams both locally and internationally to develop monoclonal antibodies as therapeutic lead candidates. I have also used in vitro antibody expression and binding kinetic analysis to answer fundamental questions about how B cells of the immune system mature their response to challanging targets.

More recently I have been involved in the Garvan Institutes program to develop therapeutic antibodies for the treatment of Covid-19.

I am an expert antibody engineer, collaborating with many research teams both locally and internationally to develop monoclonal antibodies as therapeutic lead candidates. I have also used in vitro antibody expression and binding kinetic analysis to answer fundamental questions about how B cells of the immune system mature their response to challanging targets.

More recently I have been involved in the Garvan Institutes program to develop therapeutic antibodies for the treatment of Covid-19.

Education

PhD / 2010 / University of Sydney / Australia

MSc / 2006 / University of Sydney / Australia

BSc (Molecular Biology and Genetics) / 2003 / University of Sydney / Australia

Selected Publications

Singh M, Jackson K, Wang J, Schofield P, et al. (2020) Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody. Cell 180, 878–894

Burnett D, Langley D, Schofield P, Hermes J, Chan, T, Jackson J, Bourne K, Reed J,Porebski B, Brink R, Christ D, Goodnow C (2018) Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Science 360: 223-226.

Zeraati M, Langley D, Schofield P, Moye A, Rouet R, Hughes W, Bryan T, Dinger M, Christ D (2018) I-motif DNA structures are formed in the nuclei of human cells. Nature Chemistry 10: 631-637

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling E, Randall K, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan T, Brink R, Dunn-Walters DK, Christ D and Goodnow CC (2014) Redemption of autoantibodies on anergic B cells by V-region glycosylation and mutation away from self-reactivity. PNAS 111: E2567-E2575