Sara Ballouz

Group Leader (Senior Research Officer) - Single Cell and Computational Genomics Lab

Sara Ballouz

I obtained my PhD from the University of New South Wales and the Victor Chang Cardiac Research Institute in 2013, working with Drs Merridee Wouters and Bruno Gaeta. I then moved to Cold Spring Harbor Laboratory for my postdoctoral training with Dr Jesse Gillis. In 2020, I started my own group at the

Biography

I obtained my PhD from the University of New South Wales and the Victor Chang Cardiac Research Institute in 2013, working with Drs Merridee Wouters and Bruno Gaeta. I then moved to Cold Spring Harbor Laboratory for my postdoctoral training with Dr Jesse Gillis. In 2020, I started my own group at the Garvan-Weizmann Centre for Cellular Genomics at the Garvan Institute of Medical Research.

My central scientific interest has been to understand the genetic architecture of disease. With data from the genome, transcriptome, epigenome and proteome increasing exponentially, robust tools and practices need to be established to analyse this deluge, in particular if to be applied to personalized medicine.

I obtained my PhD from the University of New South Wales and the Victor Chang Cardiac Research Institute in 2013, working with Drs Merridee Wouters and Bruno Gaeta. I then moved to Cold Spring Harbor Laboratory for my postdoctoral training with Dr Jesse Gillis. In 2020, I started my own group at the Garvan-Weizmann Centre for Cellular Genomics at the Garvan Institute of Medical Research.

My central scientific interest has been to understand the genetic architecture of disease. With data from the genome, transcriptome, epigenome and proteome increasing exponentially, robust tools and practices need to be established to analyse this deluge, in particular if to be applied to personalized medicine.

Awards and Honours

2018 - AWS Cloud Credits for Research grant
2014 - ISMB Travel Award
2009-2011 - Australian Postgraduate Award, UNSW
2009-2011 - Supplementary Engineering Award, UNSW

Education

2013 - PhD, Victor Chang Cardiac Research Institute and the University of New South Wales, Sydney - Australia
2008 - BE Bioinformatics First Class Honours, University of New South Wales, Sydney – Australia
2008 - BSc Genetics, University of New South Wales, Sydney – Australia

Selected Publications

Ballouz S, Dobin A, Gillis J. Is it time to change the reference genome? Genome Biology (2019)

Crow M, Lim N, Ballouz S, Pavlidis P, Gillis J. Predictability of human differential gene expression. PNAS. (2019)

Ballouz S, Dobin A, Gingeras TR, Gillis J. The fractured landscape of RNA-seq alignment: the default in our STARs. Nucleic Acids Research. (2018)

Crow M, Paul A, Ballouz S, Huang ZJ, Gillis J. Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor. Nature Communications. (2018)

Ballouz S, Gillis J. Strength of functional signature correlates with effect size in autism. Genome Medince. (2017)

Ballouz S, Pavlidis P, Gillis J. Using predictive specificity to determine when gene set analysis is biologically meaningful. Nucleic Acids Research. (2017)

Ballouz S, Weber M, Pavlidis P, Gillis J. EGAD: ultra-fast functional analysis of gene networks. Bioinformatics. (2017)

O'Meara MJ, Ballouz S, Shoichet BK, Gillis J. Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction. PLoS One. (2016)

Crow M, Paul A, Ballouz S, Huang ZJ, Gillis J. Exploiting single-cell expression to characterize co-expression replicability. Genome Biology. (2016)

Ballouz S, Gillis J. AuPairWise: A Method to Estimate RNA-Seq Replicability through Co-expression. PLoS Computational Biology. (2016)

Verleyen W, Ballouz S, Gillis J. Positive and negative forms of replicability in gene network analysis. Bioinformatics. (2016)

Ballouz S, Verleyen W, Gillis J. Guidance for RNA-seq co-expression network construction and analysis: safety in numbers. Bioinformatics. (2015)

Grover MP, Ballouz S, Mohanasundaram KA, George RA, Goscinski A, Crowley TM, Sherman CD, Wouters MA. Novel therapeutics for coronary artery disease from genome-wide association study data. BMC Med Genomics. (2015)