A/Prof William Sewell

Visiting Scientist - Immunopathology

A/Prof William Sewell

My research has focussed on allergic inflammation and on leukocyte surface markers. I was the first to determine the primary sequence of the T lymphocyte surface marker CD2. My group was the first to recognize that expression of the cytokine IL-5 was profoundly inhibited by glucocorticoids.  This wa

Biography

My research has focussed on allergic inflammation and on leukocyte surface markers. I was the first to determine the primary sequence of the T lymphocyte surface marker CD2. My group was the first to recognize that expression of the cytokine IL-5 was profoundly inhibited by glucocorticoids.  This was an important step leading to the development of therapeutic antibodies that inhibit the function of IL-5. 

Through my appointment to the University of NSW, I have extensive experience in education, both at the undergraduate and post-graduate level. In the post-graduate area, I have been supervisor of numerous PhD and Honours students.  I have had substantial experience in teaching medical undergraduate students at all stages of the UNSW course.  At St. Vincent’s Hospital, I work in immunopathology, where I provide special expertise in flow cytometry.

I am currently Chief Examiner in Immunopathology for the Royal College of Pathologists of Australasia, and Director of Graduate Students for the Faculty of Medicine, University of NSW.  I have served as Vice-President of the Australasian Flow Cyotmetry Group for the last 4 years and was on the organizing committee of the 2010 Annual Meeting.  I have served on numerous NHMRC Committees, and on the Editorial Board of Immunology and Cell Biology, the official journal of the Australasian Society for Immunology. 

Education

1993 - Fellow of the Royal College of Pathologists of Australasia
1984 - PhD, University of Melbourne - Australia
1978 - MBBS, First Class Honours, University of Sydney - Australia
1975 - BSc, First Class Honours with University Medal, University of Sydney - Australia

Selected Publications

Agrawal, S., Smith, S. A. B. C., Tangye, S. G. & Sewell, W. A.  Transitional B cell subsets in human bone marrow.  Clin Exp Immunol 2013; 174:53-9. 

Lam, M., Hull, L., McLachlan, R., Snidvongs, K., Chin, D., Pratt, E., Kalish, L., Sacks, R., Earls, P., Sewell, W., Harvey RJ. Clinical severity and epithelial endotypes in chronic rhinosinusitis. Int Forum Allergy Rhinol.  2013; 3:121-8.

Shim, D. S. C., Schilter, H. C., Knott, M. L., Almeida, R. A., Short, R., Mackay, C. R., Dent, L. A. & Sewell, W. A. Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF.  Immunol Cell Biol 2012; 90:553-8.

Jackson, K. J. L., Wang, Y., Gaeta, B. A., Pomat, W., Siba, P., Rimmer, J., A. Sewell, W. A., Collins, A. M. Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells. Immunogenetics. 2012; 64:3-14.

Sewell, W. A. & Smith, S. A. B. C. Polychromatic flow cytometry in the clinical laboratory.  Pathology 2011; 43:580-591.

Pratt, E., Collins, A. M., Sewell, W. A. & Harvey, R. J. Antigen selection in IgE antibodies from individuals with chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 2010; 24:416-21.

Collins, A. M., Y. Wang, V. Singh, P. Yu, K. J. Jackson & W. A. Sewell. The reported germline repertoire of human immunoglobulin kappa chain genes is relatively complete and accurate.  Immunogenetics 2008; 60:669-76. 

Shum, B. O. V., M. S. Rolph & W. A. Sewell. Mechanisms in allergic airway inflammation – lessons from studies in the mouse. Expert Rev. Mol. Med. 2008; 10(15):1-18.

Su, Y.-C., M. S. Rolph, N. G. Hansbro, C. R. Mackay & W. A. Sewell. Granulocyte-macrophage colony–stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation.  J. Immunol.  2008; 180:2600-2607.

Dahlke, I., D. J. Nott, J. Ruhno, W. A. Sewell & A. M. Collins. Antigen selection in the IgE response of allergic and non-allergic individuals. J Allerg Clin Immunol 2006; 117:1477-83.

Su, Y.-C., M. S. Rolph, M. A. Cooley, W. A. Sewell. (2006) Cyclophosphamide Augments Inflammation by Reducing Immunosuppression in a Mouse Model of Allergic Airway Disease. J Allerg Clin Immunol 2006; 117:635-641.

Belov, L., S. P. Mulligan, N. Barber, A. Woolfson, M. Scott, K. Stoner, J. S. Chrisp, W. A. Sewell, K.F. Bradstock, L. Bendall, D. S. Pascovici, M. Thomas, W. Erber, P. Huang, M. Sartor, G. A. Young, J. S. Wiley, S. Juneja, W. G. Wierda, A. R. Green, M. J. Keating & R. I. Christopherson. Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray. Br. J. Haematol. 2006; 135:184-97.