Principal Research Fellow
Daniel Christ is Head of Antibody Therapeutics and Director of the Centre of Targeted Therapy at the Garvan Institute of Medical Research in Sydney, Australia
He trained at the Swiss Federal Institute of Technology (ETH), and at Cambridge University, where he worked with British biotechnology pioneer Sir Gregory Winter at the MRC Laboratory of Molecular Biology. Winter had shown that in vitro evolution technology (such as phage display) can be used for the generation of therapeutic antibodies, initiating a multi-billion dollar biotechnology industry. At Cambridge, Christ and Winter further developed monoclonal antibody technology, particularly in the field of domain antibodies. He was elected a Fellow of Trinity College (Cambridge University) at age 29 and was involved the foundation of Domantis Ltd (sold to GSK for £230 million in 2006).
In 2007 Daniel joined the Garvan as Head of Antibody Therapeutics, to translate structural and genomic advances into drug candidates and treatments for cancer and inflammatory conditions.
His contributions have been recognised by multiple prizes and appointments, including the NHMRC Excellence award, and by the award of more than 15 competitive research grants from the NHMRC and ARC in recent years.
Awards and Honours
2002 - Fellow, Trinity College, Cambridge University
1999 - ERS PhD Scholarship, Trinity College, Cambridge University
1999 - Swiss Federal Institute of Technology ETH Award
1999 - Dipl Natw (MSc), Swiss Federal Institute of Technology (ETH) - Switzerland
Deborah L Burnett, David B Langley, Peter Schofield, Jana R Hermes, Tyani D Chan, Jennifer Jackson, Katherine Bourne, Joanne H Reed, Benjamin T Porebski, Robert Brink, Daniel Christ* and Christopher C Goodnow* (2018) [Joint senior and corresponding authors] Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination. Science Vol. 360, Issue 6385: 223-226
Mahdi Zeraati, David B. Langley, Peter Schofield, Aaron L. Moye, Romain Rouet, William E. Hughes, Tracy M. Bryan, Marcel E. Dinger* and Daniel Christ* (2018) I-motif DNA structures are formed in the nuclei of human cells. Nature Chemistry doi:10.1038/s41557-018-0046-3
Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, Jenny Jackson, Peter Schofield, Elissa K. Deenick, Cecile King, Tri Giang Phan, Kylie E. Webster, Jonathan Sprent and Daniel Christ (2017) Potent antitumour activity of IL-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells. Nature Communications 8:15373
Romain Rouet, David B. Langley, Peter Schofield, Mary Christie, Brendan Roome, Benjamin T. Porebski, Ashley M. Buckle, Ben E. Clifton, Colin L. Jackson, Daniela Stock and Daniel Christ (2017) Structural reconstruction of protein ancestry. Proc Natl Acad Sci USA 14(15):3897-3902
Rodrigo Vazquez-Lombardi, Damien Nevoltris, Ansha Luthra, Peter Schofield, Carsten Zimmermann and Daniel Christ (2017) Transient expression of human antibodies in mammalian cells. Nature Protocols 13, 99–117
Rodrigo Vazquez-Lombardi, Tri Giang Phan, Carsten Zimmermann, David Lowe, Lutz Jermutus and Daniel Christ (2015) Challenges and opportunities for non-antibody scaffold drugs. Drug Discovery Today 20 (10), 1271-1283
Andrew Bradbury et al. (2015) Reproducibility: Standardize antibodies used in research. Nature 518(7537): 27-29 [co-signatory]
Sabouri Z, Peter Schofield, Keisuke Horikawa, Emily Spierings, David Kipling, Katrina L Randall, David Langely, Brendan Roome, Rodrigo Vazquez-Lombardi, Romain Rouet, Jana Hermes, Tyani D Chan, Robert Brink, Deborah K Dunn-Walters, Daniel Christ* and Christopher C Goodnow* (2014) Redemption of autoantibodies on anergic B cells by V-region glycosylation and mutation away from self-reactivity. Proc Natl Acad Sci USA 111(25): 2567-2575 [*joint senior and corresponding authors]
Romain Rouet and Daniel Christ (2014) Bispecific antibodies with native chain structure. Nature Biotechnology 32(2): 136-7
Domique Gatto, Katherine Wood, Caminschi I, Danielle Murphy-Durland, Peter Schofield, Daniel Christ, Karupiah G and Robert Brink. (2013) The chemotactic receptor EBI2 regulates the homeostasis, localization and immune function of splenic dendritic cells. Nature Immunology 14(5): 446-453
Kip Dudgeon, Romain Rouet, Iris Kokmeijer, Peter Schofield, Jessica Stolp, David Langely, Daniela Stock and Daniel Christ (2012) General strategy for the generation of human antibody variable domains with increased aggregation resistance. Proc Natl Acad Sci U S A. 109: 10879-10884
Romain Rouet, Kip Dudgeon, Peter Schofield, David Lowe, Lutz Jermutus and Daniel Christ (2012) Expression of high affinity antibody fragments in bacteria. Nature Protocols 7: 364-373
Daniel Christ and Greg Winter (2003) Identification of functional similarities between proteins using directed evolution, Proc Natl Acad Sci USA 100:13202-13206