Professor Daniel Christ
Professor Daniel Christ is Head of Antibody Therapeutics and Director of the Centre for Targeted Therapy at the Garvan Institute of Medical Research in Sydney, Australia.
He was educated at the Swiss Federal Institute of Technology (ETH) and at Cambridge University, where he worked at the MRC Laboratory of Molecular Biology with Nobel Laureate Sir Gregory Winter, a pioneer of the British biotechnology industry. At Cambridge, he and Sir Winter developed monoclonal antibody technology, in the field of phage display and single domain antibodies. He was elected a Fellow of Trinity College (Cambridge University) at age 29 and was involved the foundation of Domantis Ltd (sold to GSK for £230 million in 2006).
Daniel joined Garvan in 2007 as Head of Antibody Therapeutics, to translate structural and genomic advances into drug candidates and treatments for cancer and inflammatory conditions. He is particularly well known for using both in vitro and in vivo selection strategies for generating antibodies with superior biophysical and targeting properties. His work has allowed the functional characterisation of important targets including A20, EBI2, the CD25/CD122/CD132 (IL2R) system, and has validated the existence of i-motif DNA in human cells. His contributions have been recognised by multiple prizes and appointments, including the NHMRC Excellence award, and by the award of more than 15 competitive research grants from the NHMRC and ARC in recent years.
Daniel and co-workers use high-throughput selection and sequencing approaches in combination with biochemical and X-ray crystallographic analyses to study and engineer the interaction between therapeutic antibodies and their targets.
In collaboration with UNSW's Kirby Institute, Daniel is currently developing antibodies designed to target the surface proteins of SARS-CoV-2, the novel coronavirus that causes COVID-19. This antiviral therapy could provide ‘passive immunity’ to at-risk individuals including front-line health workers.
- 1999ERS PhD Scholarship - Trinity College - Cambridge University
- 1999Swiss Federal Institute of Technology ETH Studer Award
- 2002Fellow - Trinity College - Cambridge University
- 2013NHMRC Excellence Award (top ranked fellowship)
- 2023International journal of biological macromolecules10.1016/j.ijbiomac.2023.127596
An antibody fragment-decorated liposomal conjugate targets Philadelphia-like acute lymphoblastic leukemia.
- 2023Nucleic acids research10.1093/nar/gkad592
Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif.
- 2023Molecular therapy : the journal of the American Society of Gene Therapy10.1016/j.ymthe.2023.03.032
Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy.
- 2023Nature cancer10.1038/s43018-023-00516-z
Advances in antibody-based therapy in oncology.
- 2023Nature communications10.1038/s41467-023-36295-5
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.