Kylie James

Group Leader Immunogenomics of inflammatory bowel disease (Spinak Fellow) - Garvan-Weizmann Centre for Cellular Genomics (GWCCG) – Research

Kylie James

Kylie is the Team Leader of the Immunogenomics of Inflammatory Bowel Disease team. She completed her PhD at University of Queensland working with Dr Ashraful Haque at QIMR Berghofer Medical Research Institute. In this role, she determined the response kinetics of T helper cells during blood-stage ma

Biography

Kylie is the Team Leader of the Immunogenomics of Inflammatory Bowel Disease team. She completed her PhD at University of Queensland working with Dr Ashraful Haque at QIMR Berghofer Medical Research Institute. In this role, she determined the response kinetics of T helper cells during blood-stage malaria. Kylie then continued to pursue her interest in the immune system as a postdoctoral researcher with Dr Sarah Teichmann at the Wellcome Sanger Institute and Junior Research Fellow at Christ’s College, University of Cambridge, UK. Her work redefined our understanding of the balance of immune and microbial cells across the healthy human colon. In 2021, Kylie returned to Australia to start her own team as Spinak Fellow and supported by an NHMRC Investigator Grant.

 

The Immunogenomics of Inflammatory Bowel Disease team investigates how environmental factors shape gut immune cell and microbial landscapes in health and disease. To achieve this goal, the team apply single-cell genomics and computational approaches to reconstruct cellular microenvironments, developmental hierarchies and interactions.

Kylie is the Team Leader of the Immunogenomics of Inflammatory Bowel Disease team. She completed her PhD at University of Queensland working with Dr Ashraful Haque at QIMR Berghofer Medical Research Institute. In this role, she determined the response kinetics of T helper cells during blood-stage malaria. Kylie then continued to pursue her interest in the immune system as a postdoctoral researcher with Dr Sarah Teichmann at the Wellcome Sanger Institute and Junior Research Fellow at Christ’s College, University of Cambridge, UK. Her work redefined our understanding of the balance of immune and microbial cells across the healthy human colon. In 2021, Kylie returned to Australia to start her own team as Spinak Fellow and supported by an NHMRC Investigator Grant.

 

The Immunogenomics of Inflammatory Bowel Disease team investigates how environmental factors shape gut immune cell and microbial landscapes in health and disease. To achieve this goal, the team apply single-cell genomics and computational approaches to reconstruct cellular microenvironments, developmental hierarchies and interactions.

Awards and Honours

- NHMCR Investigator Grant (2020-2025)
- Spinak Fellowship (2021-2024)
- Christ’s College Junior Research Fellowship (2018-2020)

Education

2016, PhD, University of Queensland, Australia
2011, BSc (Hons), University of Queensland, Australia

Fundings

NHMRC Investigator Grant (2021-2026)

Junior Research Fellowship, Christ's College, University of Cambridge (2018-2020)

Selected Publications

James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polanski K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA, “Distinct microbial and immune niches of the human colon” Nat. Immunol. (2020), doi.org/10.1038/s41590-020-0602-z

 

Efremova M*, Vento-Tormo R*, Park JE*, Teichmann SA, James KR, “Immunology in the era of single-cell technologies”, Ann. Rev. Immunol. (2020), doi.org/10.1146/annurev-immunol-090419-020340

 

James KR, King HW, “Germs and germlines: How ‘public’ B cell clones evolve in the gut”, Immunol. Cell Biol., (2020), doi.org/10.1111/imcb.12340

 

Hewitson JP*, West K*, James KR, Rani G, Dey N, Romano A, Brown N, Teichmann SA, Kaye PM, Lagos D, “Malat1 loss promotes immunity through suppression of Maf and IL-10 in Th cells”, J. Immunol., (2020), doi.org/10.4049/jimmunol.1900940

 

Kunz DJ, Gomes T, James KR, “Immune cell dynamics unfolded by single-cell technologies”. Front. Immunol., (2018), doi.org/10.3389/fimmu.2018.01435

 

Lonnberg T*, Svensson V*, James KR*, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MSF, Fogg LG, Nair AS, Liligeto UN, Stubbington MJT, Ly LH, Bagger FO, Zweissele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA, “Single-cell RNA-sequencing resolves a CD4+ T helper cell fate bifurcation”, Sci. Immunol. (2017), doi.org/10.1126/sciimmunol.aal2192

 

*equal contribution