Owen Siggs

Visiting Scientist - Immunogenomics Lab

Owen Siggs

Dr Owen Siggs is an early-career clinician-scientist and an inaugural Snow Fellow, with a career focus on the clinical impact of germline and somatic genetic variation. Owen trained in science and clinical medicine in Adelaide, in immunology and genomics at the John Curtin School of Medical Researc

Biography

Dr Owen Siggs is an early-career clinician-scientist and an inaugural Snow Fellow, with a career focus on the clinical impact of germline and somatic genetic variation.

Owen trained in science and clinical medicine in Adelaide, in immunology and genomics at the John Curtin School of Medical Research with Professor Chris Goodnow, as a General Sir John Monash Scholar at The Scripps Research Institute in California with Nobel Laureate Professor Bruce Beutler, and at the University of Oxford with the Nuffield Professor of Medicine Richard Cornall. He was then a Sir Henry Wellcome Postdoctoral Fellow at The Wellcome Trust Sanger Institute and a Junior Research Fellow at the University of Cambridge, and a Visiting Fellow at the Broad Institute of MIT and Harvard.

His research career has spanned the use of large-scale genome-wide mutagenesis to discover the function of genes essential for immunity, to the use of exome and genome sequencing to diagnose severe inherited diseases. His current interests include the use of large-scale population and single cell genomics to understand the clinical impact of germline and somatic genetic variation, and the application of this information in clinical practice.

Dr Owen Siggs is an early-career clinician-scientist and an inaugural Snow Fellow, with a career focus on the clinical impact of germline and somatic genetic variation.

Owen trained in science and clinical medicine in Adelaide, in immunology and genomics at the John Curtin School of Medical Research with Professor Chris Goodnow, as a General Sir John Monash Scholar at The Scripps Research Institute in California with Nobel Laureate Professor Bruce Beutler, and at the University of Oxford with the Nuffield Professor of Medicine Richard Cornall. He was then a Sir Henry Wellcome Postdoctoral Fellow at The Wellcome Trust Sanger Institute and a Junior Research Fellow at the University of Cambridge, and a Visiting Fellow at the Broad Institute of MIT and Harvard.

His research career has spanned the use of large-scale genome-wide mutagenesis to discover the function of genes essential for immunity, to the use of exome and genome sequencing to diagnose severe inherited diseases. His current interests include the use of large-scale population and single cell genomics to understand the clinical impact of germline and somatic genetic variation, and the application of this information in clinical practice.

Awards and Honours

2021- Snow Fellowship
2013-14 Junior Research Fellowship, St Edmund's College, University of Cambridge
2013-14 Sir Henry Wellcome Postdoctoral Fellowship
2007-12 Skaggs Oxford Scholar
2007-10 General Sir John Monash Scholar

Education

2017 MD, Flinders University
2012 DPhil, University of Oxford, Oxford, UK
2012 PhD, The Scripps Research Institute, La Jolla, CA, USA
2005 BSc(Hons), The Australian National University
2004 BSc, University of Adelaide

Fundings

Snow Medical
Rebecca Cooper Foundation
Ophthalmic Research Institute of Australia

Selected Publications

Zammit NW*, Siggs OM*, Gray PE, Horikawa K, Langley DB, Walters SN, et al. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019;20: 1299–1310.
Siggs OM, Russell A, Singh-Grewal D, Wong M, Chan P, Craig ME, et al. Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif. Front Immunol. 2019;10: 1544.
MacGregor S, Ong J-S, An J, Han X, Zhou T, Siggs OM, et al. Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nat Genet. 2018;50: 1067–1071.
Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, et al. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A. 2016;113: E3706–15.
Souma T*, Tompson SW*, Thomson BR, Siggs OM, Kizhatil K, Yamaguchi S, et al. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest. 2016;126: 2575–2587.
Siggs OM*, Xiao N*, Wang Y, Shi H, Tomisato W, Li X, et al. iRhom2 is required for the secretion of mouse TNFα. Blood. 2012;119: 5769–5771.
Siggs OM, Li X, Xia Y, Beutler B. ZBTB1 is a determinant of lymphoid development. J Exp Med. 2012;209: 19–27.
Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, et al. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 2011;12: 434–440.
Marino D*, Giam M*, Hughes PD*, Siggs OM, Heger K, O’Reilly LA, et al. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol. 2009;186: 355–362.
Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, et al. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity. 2007;27: 912–926.