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Owen Siggs

Associate Professor Owen Siggs

Program Director - Genomics and Inherited Disease / Laboratory Head - Genomic Medicine
Genomic Medicine Lab

Associate Professor Owen Siggs is a mid-career clinician-scientist and Snow Fellow. He is a member of the Garvan Faculty and Centre for Population Genomics, head of the Genomic Medicine Lab, and co-Director of the Garvan Genomics and Inherited Disease Program.

Owen trained in science and clinical medicine in Adelaide, in immunology and genomics at the John Curtin School of Medical Research with Professor Chris Goodnow, as a John Monash Scholar at The Scripps Research Institute in California with Nobel Laureate Professor Bruce Beutler, and at the University of Oxford with the Nuffield Professor of Medicine Richard Cornall. He was then a Sir Henry Wellcome Postdoctoral Fellow at the Wellcome Sanger Institute and a Junior Research Fellow at the University of Cambridge, and a Visiting Fellow at the Broad Institute of MIT and Harvard.

His current research interests lie in the genomic architecture of immune and ophthalmic disease, and leverage large clinical and genomic datasets, and new genomic technologies. He is actively engaged in the translation of these findings into clinical practice, particularly in the area of genomic risk prediction, and is a co-founder and director of Seonix Bio.


  • 2021Dr. David L. Epstein Award
  • 2021Snow Fellow
  • 2013Junior Research Fellow - University of Cambridge
  • 2013Sir Henry Wellcome Postdoctoral Fellow
  • 2007John Monash Scholar
  • 2007Skaggs Oxford Scholar

Selected publications

See all publications
  • 2023

    High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma.

    Henry N Marshall, Sean Mullany, Xikun Han, Ayub Qassim, Weixiong He, Mark M Hassall, Joshua Schmidt, Daniel Thomson, Thi Thi Nguyen, Ella C Berry, Lachlan S W Knight, Georgina L Hollitt, Bronwyn Ridge, Angela Schulz, Richard A Mills, Paul R Healey, Ashish Agar, Anna Galanopoulos, John Landers, Stuart L Graham, Alex W Hewitt, Robert J Casson, Stuart MacGregor, Owen M Siggs, Jamie E Craig
  • 2021
    JAMA Ophthalmology10.1001/jamaophthalmol.2021.2440

    Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.

    Owen M Siggs, Xikun Han, Ayub Qassim, Emmanuelle Souzeau, Shilpa Kuruvilla, Henry N Marshall, Sean Mullany, David A Mackey, Alex W Hewitt, Puya Gharahkhani, Stuart MacGregor, Jamie E Craig
  • 2019
    Nature Immunology10.1038/s41590-019-0492-0

    Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

    Nathan W Zammit, Owen M Siggs, Paul E Gray, Keisuke Horikawa, David B Langley, Stacey N Walters, Stephen R Daley, Claudia Loetsch, Joanna Warren, Jin Yan Yap, Daniele Cultrone, Amanda Russell, Elisabeth K Malle, Jeanette E Villanueva, Mark J Cowley, Velimir Gayevskiy, Marcel E Dinger, Robert Brink, David Zahra, Geeta Chaudhri, Gunasegaran Karupiah, Belinda Whittle, Carla Roots, Edward Bertram, Michiko Yamada, Yogesh Jeelall, Anselm Enders, Benjamin E Clifton, Peter D Mabbitt, Colin J Jackson, Susan R Watson, Craig N Jenne, Lewis L Lanier, Tim Wiltshire, Matthew H Spitzer, Garry P Nolan, Frank Schmitz, Alan Aderem, Benjamin T Porebski, Ashley M Buckle, Derek W Abbott, John B Ziegler, Maria E Craig, Paul Benitez-Aguirre, Juliana Teo, Stuart G Tangye, Cecile King, Melanie Wong, Murray P Cox, Wilson Phung, Jia Tang, Wendy Sandoval, Ingrid E Wertz, Daniel Christ, Christopher C Goodnow, Shane T Grey