Chenxu Yan

Role: PhD Student
Lab/Group: Obesity and Metabolic Disease Research Group

Selected publications

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2025
Cell Reports10.1016/j.celrep.2025.115691
ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion.
Nancy Sue, Le May Thai, Ebru Boslem, Kwan Yi Chu, Chenxu Yan, Leanne Mackin, William E Hughes, Angela Fontaine-Titley, Deborah Barkauskas, Louise Cottle, Helen E Thomas, Carsten Schmitz-Peiffer, Yan-Chuan Shi, Paul Timpson, David Herrmann, Martin Whitham, Trevor J Biden
2023
Molecular Metabolism10.1016/j.molmet.2023.101845
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K Boyer, Ashleigh M Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B Stephens, Kazunori Imaizumi, Trevor J Biden
2023
IScience10.1016/j.isci.2023.106477
β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.
Le May Thai, Liam O'Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A Kebede, Robert Brink, Gregory J Cooney, Katharine M Irvine, Samuel N Breit, Tri G Phan, Alexander Swarbrick, Trevor J Biden
2022
Journal of Cellular Physiology10.1002/jcp.30719
Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.
Chen-Liang Zhang, Yi-Zhang Lin, Qi Wu, Chenxu Yan, Matthew Wai-Kin Wong, Fan Zeng, Ping Zhu, Kelsey Bowes, Kailun Lee, Xuan Zhang, Zhi-Yuan Song, Shu Lin, Yan-Chuan Shi
2021
Nature Communications10.1038/s41467-021-22925-3
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.
Chenxu Yan, Tianshu Zeng, Kailun Lee, Max Nobis, Kim Loh, Luoning Gou, Zefeng Xia, Zhongmin Gao, Mohammed Bensellam, Will Hughes, Jackie Lau, Lei Zhang, Chi Kin Ip, Ronaldo Enriquez, Hanyu Gao, Qiao-Ping Wang, Qi Wu, Jody J Haigh, D Ross Laybutt, Paul Timpson, Herbert Herzog, Yan-Chuan Shi

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Chenxu Yan

Selected publications

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion.

Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.

Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.