Chenxu Yan

Role: PhD Student
Lab/Group: Brink Lab

Selected publications

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2025
Endocrinology10.1210/endocr/bqaf118
Emerging Insights into Brown Adipose Tissue Crosstalk With Pancreatic β-Cells in Metabolic Regulation.
Chenxu Yan, George Burley, Hanyu Gao, Yan-Chuan Shi
2025
Cell Reports10.1016/j.celrep.2025.115691
ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion.
Nancy Sue, Le May Thai, Ebru Boslem, Kwan Yi Chu, Chenxu Yan, Leanne Mackin, William E Hughes, Angela Fontaine-Titley, Deborah Barkauskas, Louise Cottle, Helen E Thomas, Carsten Schmitz-Peiffer, Yan-Chuan Shi, Paul Timpson, David Herrmann, Martin Whitham, Trevor J Biden
2023
Molecular Metabolism10.1016/j.molmet.2023.101845
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K Boyer, Ashleigh M Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B Stephens, Kazunori Imaizumi, Trevor J Biden
2023
IScience10.1016/j.isci.2023.106477
β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.
Le May Thai, Liam O'Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A Kebede, Robert Brink, Gregory J Cooney, Katharine M Irvine, Samuel N Breit, Tri G Phan, Alexander Swarbrick, Trevor J Biden
2022
Journal of Cellular Physiology10.1002/jcp.30719
Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.
Chen-Liang Zhang, Yi-Zhang Lin, Qi Wu, Chenxu Yan, Matthew Wai-Kin Wong, Fan Zeng, Ping Zhu, Kelsey Bowes, Kailun Lee, Xuan Zhang, Zhi-Yuan Song, Shu Lin, Yan-Chuan Shi

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Chenxu Yan

Selected publications

Emerging Insights into Brown Adipose Tissue Crosstalk With Pancreatic β-Cells in Metabolic Regulation.

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion.

Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.

Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor.