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Dr Hasindu Gamaarachchi

Role
Visiting Scientist
Lab/Group
Deveson Lab

Hasindu Gamarachchi is a senior lecturer at the School of Computer Science and Engineering, UNSW Sydney. He is also a visiting scientist in the Genomic Technologies Group at Garvan Institute of Medical Research. From 2020 to 2022, he worked as a Genomics Computing Research Scientist at Garvan Institute of Medical Research. Hasindu completed his PhD in Computer Science and Engineering at UNSW Sydney in 2020. He has served as a lecturer at the Department of Computer Engineering and a resource person at NVIDIA research centre at the University of Peradeniya. He completed his bachelor’s degree with first-class honours in Computer Engineering from the University of Peradeniya, Sri Lanka in 2015.

Hasindu Gamaarachchi focuses on the design, development and optimisation of bioinformatics software and hardware for real-time sequencing data analysis; and, prototyping novel domain-specific computer systems for efficient genomics data analysis. He has more than ten years of experience in embedded computing systems, computer architecture, general-purpose computing with the use of a Graphics Processing Unit (GPU), high-performance computing and low-level system programming, which he leverages for the architecture-aware design of efficient computational systems for bioinformatics. Examples of his work include: an iterative genome assembly method that uses nanopore adaptive sampling to produce near-complete genome assemblies (Gamaarachchi, Nature Communications 2025); a novel domain-specific file format for efficient nanopore data processing (Gammaarachchi, Nature Biotechnology 2022); and, GPU-accelerated adaptive banded event alignment algorithm which is a core component in nanopore data analysis (Gammaarachchi, BMC Bioinformatics 2020).

Awards

  • 2025Australian Museum Macquarie University Eureka Prize for Outstanding Early Career Researcher
  • 2024“Torsten Seemann” Outstanding Bioinformatics Software Developer Award – Australian Bioinformatic And Computational Biology Society (ABACBS)
  • 2021Dean's Award for Outstanding PhD Theses awarded by UNSW Sydney
  • 2021Outstanding PhD Thesis award by Australian Bioinformatics And Computational Biology Society (ABACBS)
  • 2020Grand finalist (third place winner) in the Association for Computing Machinery Student Research Competition (ACM SRC)
  • 2019Best poster award in Australasian Genomic Technologies Association (AGTA) Conference
  • 2019First place in the Association for Computing Machinery Special Interest Group on Embedded Systems Student Research Competition (ACM SIGBED SRC) at Embedded Systems Week Conference
  • 2016Best presenter award in Present Around The World 2016 organised by Institution of Engineering and Technology-Young Professionals Section (IET-YPS) Sri Lanka
  • 2016Best technical paper award in Annual Technical Conference of Institution of Engineering and Technology-Young Professionals Section (IET-YPS) Sri Lanka
  • 2016C.A. Hewavitharana Prize awarded by University of Peradeniya for best performance in Engineering
  • 2016Industrial and Financial Systems (IFS) Gold Medal awarded by University of Peradeniya for best perfrmance in Computer Engineering

Education

  • 2015Bachelor of Science (Bachelor of Science (B.S)), Computer EngineeringUniversity of Peradeniya, Sri Lanka
  • 2020Doctor of Philosophy (Doctor of Philosophy (Ph.D)), Computer EngineeringUniversity of New South Wales, Australia

Selected publications

See all publications
  • 2025
    Nature Communications10.1038/s41467-025-65410-x

    Targeted sequencing and iterative assembly of near-complete genomes.

    Hasindu Gamaarachchi, Igor Stevanovski, Jillian M Hammond, Andre L M Reis, Melissa Rapadas, Kavindu Jayasooriya, Tonia Russell, Dennis Yeow, Yvonne Hort, Chirag Patel, Andrew J Mallett, Elaine Stackpoole, Lauren Roman, Luke W Silver, Carolyn J Hogg, Louise M Streeting, Ozren Bogdanovic, Renata Coelho Rodrigues Noronha, Luís Adriano Santos do Nascimento, Adauto Lima Cardoso, Arthur Georges, Haoyu Cheng, Hardip R Patel, Kishore Raj Kumar, Amali C Mallawaarachchi, Ira W Deveson
  • 2025
    Genome Research10.1101/gr.280090.124

    A new compression strategy to reduce the size of nanopore sequencing data.

    Kavindu Jayasooriya, Sasha P Jenner, Pasindu Marasinghe, Udith Senanayake, Hassaan Saadat, David Taubman, Roshan Ragel, Hasindu Gamaarachchi, Ira W Deveson
  • 2025
    Bioinformatics (Oxford, England)10.1093/bioinformatics/btaf151

    Realfreq: real-time base modification analysis for nanopore sequencing.

    Suneth Samarasinghe, Ira Deveson, Hasindu Gamaarachchi
  • 2025
    Bioinformatics (Oxford, England)10.1093/bioinformatics/btaf111

    Leveraging basecaller's move table to generate a lightweight k-mer model for nanopore sequencing analysis.

    Hiruna Samarakoon, Yuk Kei Wan, Sri Parameswaran, Jonathan Göke, Hasindu Gamaarachchi, Ira W Deveson
  • 2025
    Nature Methods10.1038/s41592-025-02623-4

    A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines.

    Ying Chen, Nadia M Davidson, Yuk Kei Wan, Fei Yao, Yan Su, Hasindu Gamaarachchi, Andre Sim, Harshil Patel, Hwee Meng Low, Christopher Hendra, Laura Wratten, Christopher Hakkaart, Chelsea Sawyer, Viktoriia Iakovleva, Puay Leng Lee, Lixia Xin, Hui En Vanessa Ng, Jia Min Loo, Xuewen Ong, Hui Qi Amanda Ng, Jiaxu Wang, Wei Qian Casslynn Koh, Suk Yeah Polly Poon, Dominik Stanojevic, Hoang-Dai Tran, Kok Hao Edwin Lim, Shen Yon Toh, Philip Andrew Ewels, Huck-Hui Ng, N Gopalakrishna Iyer, Alexandre Thiery, Wee Joo Chng, Leilei Chen, Ramanuj DasGupta, Mile Sikic, Yun-Shen Chan, Boon Ooi Patrick Tan, Yue Wan, Wai Leong Tam, Qiang Yu, Chiea Chuan Khor, Torsten Wüstefeld, Alexander Lezhava, Ploy N Pratanwanich, Michael I Love, Wee Siong Sho Goh, Sarah B Ng, Alicia Oshlack, , Jonathan Göke