Arcadi completed his degree in Molecular Biology at the University of Milan, Italy in 1998.  He became fascinated by the field of cancer immunology and immunotherapy and in 2008 gained a PhD in Molecular and Cellular Pathology at the University of Parma, Italy. His studies shed light on the mechanisms driving anti-tumor immune response elicited by engineered T lymphocytes expressing tumor specific antigens.

He then moved to the Ludwig Institute for Cancer Research in Brussels, where he joined the group of Prof Pierre Coulie as Postdoctoral Fellow. His studies involved some fundamental aspects of the anti-tumor immune response, like the transcriptional profile of tumor infiltrating CD8 T lymphocytes in human melanoma samples, and the characterisation of intratumoral lymphoid neogenesis in human subcutaneous metastasis.

In 2011 he joined the group of Prof David Thomas at the Peter MacCallum Cancer Centre in Melbourne, where he focused his attention on defining the general principles governing how human cancer cells adapt and evolve in response to selective pressures imposed by therapeutics. These studies emphasise the molecular and genetic mechanisms used by tumor cells to increase the levels of genetic instability and accelerate stress-induced adaptive evolution.

In 2014, the group moved to The Kinghorn Cancer Centre at the Garvan Institute in Sydney, and Arcadi is actively involved in the development of in vitro and in silico models to define cancer risks associated with germline mutations in tumor suppressor genes.