A/Prof Elissa Deenick
Biography
Elissa undertook her PhD with Dr Phil Hodgkin at the Centenary Institute/University of Sydney. Following her PhD she moved to Canada to take up a postdoctoral position in the lab of Dr Pam Ohashi at the University of Toronto looking at the signalling pathways controlling T cell activation and tolerance.
In 2007 she returned to Sydney to work at the Garvan Institute, where she is currently a Lab Head in the Immunity and Inflammation theme. Here she has continued her interests in lymphocyte activation and differentiation and how this is controlled to ensure protection against infection while avoiding harmful immune responses like allergy and autoimmunity. She does this by studying both patients with immune disease and mouse models of these conditions.
Elissa undertook her PhD with Dr Phil Hodgkin at the Centenary Institute/University of Sydney. Following her PhD she moved to Canada to take up a postdoctoral position in the lab of Dr Pam Ohashi at the University of Toronto looking at the signalling pathways controlling T cell activation and tolerance.
In 2007 she returned to Sydney to work at the Garvan Institute, where she is currently a Lab Head in the Immunity and Inflammation theme. Here she has continued her interests in lymphocyte activation and differentiation and how this is controlled to ensure protection against infection while avoiding harmful immune responses like allergy and autoimmunity. She does this by studying both patients with immune disease and mouse models of these conditions.
Education
BMedSci (Hons) - University of Sydney, Australia
Selected Publications
Lau A, Avery DT, Jackson K, Lenthall H, Volpi S, Brigden H, Russell AJ, Bier J, Reed JH, Smart JM, Cole T, Choo S, Gray PE, Berglund LJ, Hsu P, Wong M, O'Sullivan M, Boztug K, Meyts I, Uzel G, Notarangelo LD, Brink R, Goodnow CC, Tangye SG, and Deenick EK (2020) Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production. J Exp Med 217: 45.
Bier J, Rao G, Payne K, Brigden H, French E, Pelham SJ, Lau A, Lenthall H, Edwards ESJ, Smart JM, Cole TS, Choo S, Joshi AY, Abraham RS, O'Sullivan M, Boztug K, Meyts I, Gray PE, Berglund LJ, Hsu P, Wong M, Holland SM, Notarangelo LD, Uzel G, Ma CS, Brink R, Tangye SG, and Deenick EK (2019) Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells. J Allergy Clin Immunol 144: 236-53.
Tangye SG, Bier J, Lau A, Nguyen T, Uzel G, and Deenick EK (2019) Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect. J Clin Immunol 39: 148-58.
Avery DT, Kane A, Nguyen T, Lau A, Nguyen A, Lenthall H, Payne K, Shi W, Brigden H, French E, Bier J, Hermes JR, Zahra D, Sewell WA, Butt D, Elliott M, Boztug K, Meyts I, Choo S, Hsu P, Wong M, Berglund LJ, Gray P, O'Sullivan M, Cole T, Holland SM, Ma CS, Burkhart C, Corcoran LM, Phan TG, Brink R, Uzel G, Deenick EK, and Tangye SG (2018) Germline-activating mutations in PIK3CD compromise B cell development and function. J Exp Med 215: 2073-95.
Deenick EK, Morey A, Danta M, Emmett L, Fay K, Gracie G, Ma CS, Macintosh R, Smith SABC, Sasson SC, Sewell WA, Cowley M, Tangye SG, Kelleher AD, Circa, and Phan TG (2018) Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency. J Clin Immunol 38: 159-62.
Deenick EK, Pelham SJ, Kane A, and Ma CS (2018) Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses. Front Immunol 9: 168.
Kong X-F, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G, Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, Arlehamn CSL, Rao G, Picard C, Lasseau T, Latorre D, Hambleton S, Deswarte C, Itan Y, Abarca K, Moraes-Vasconcelos D, Ailal F, Ikinciogullari A, Dogu F, Benhsaien I, Sette A, Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, and Casanova J-L (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol 19: 973-85.
Martinez-Barricarte R, Markle JG, Ma CS, Deenick EK, Ramírez-Alejo N, Mele F, Latorre D, Mahdaviani SA, Aytekin C, Mansouri D, Bryant VL, Jabot-Hanin F, Deswarte C, Nieto-Patlán A, Surace L, Kerner G, Itan Y, Jovic S, Avery DT, Wong N, Rao G, Patin E, Okada S, Bigio B, Boisson B, Rapaport F, Seeleuthner Y, Schmidt M, Ikinciogullari A, Dogu F, Tanir G, Tabarsi P, Bloursaz MR, Joseph JK, Heer A, Kong X-F, Migaud M, Lazarov T, Geissmann F, Fleckenstein B, Arlehamn CL, Sette A, Puel A, Emile J-F, van de Vosse E, Quintana-Murci L, Di Santo JP, Abel L, Boisson-Dupuis S, Bustamante J, Tangye SG, Sallusto F, and Casanova J-L (2018) Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23. Sci Immunol 3: eaau6759.
Cottineau J, Kottemann MC, Lach FP, Kang Y-H, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay J-P, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova J-L, Smogorzewska A, and Jouanguy E (2017) Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest 127: 1991-2006.
Kane A, Lau A, Brink R, Tangye SG, and Deenick EK (2016) B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome. J Allergy Clin Immunol 138: 1455-8.e3.
Pelham SJ, Lenthall HC, Deenick EK, and Tangye SG (2016) Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome. J Allergy Clin Immunol 138: 1210-3.e5.
Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CSL, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay J-P, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, and Casanova J-L (2015) Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science 349: aaa4282-613.
