Associate Professor Elissa Deenick
Associate Professor Elissa Deenick undertook her PhD with Dr Phil Hodgkin at the Centenary Institute/University of Sydney. Following her PhD, she moved to Canada to take up a postdoctoral position in the lab of Dr Pam Ohashi at the University of Toronto looking at the signalling pathways controlling T cell activation and tolerance. In 2007 she returned to Sydney to work at the Garvan Institute of Medical Research, where she is currently a Lab Head in the Immunity and Inflammation theme. Here she has continued her interests in lymphocyte activation and differentiation and how this is controlled to ensure protection against infection while avoiding harmful immune responses like allergy and autoimmunity. She does this by studying both patients with immune disease and mouse models of these conditions.
- 2023The Journal of experimental medicine10.1084/jem.20221020
Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.
- 2022Immunological reviews10.1111/imr.13067
The role of dysregulated PI3Kdelta signaling in human autoimmunity.
- The Journal of experimental medicine10.1084/jem.20191336
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
- 2020Immunology and cell biology10.1111/imcb.12345
Molecular and cellular mechanisms underlying defective antibody responses.
- 2019The Journal of allergy and clinical immunology10.1016/j.jaci.2019.01.033
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4 T cells.