A/Prof Ozren Bogdanovic
Research Level
Biography
Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis. Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - Spain) where he led multiple developmental genetics projects and participated in the adaptation of next-generation sequencing technologies to vertebrate embryonic material.
In 2013 Ozren started his postdoctoral studies at the University of Western Australia where he conducted research in the field of developmental and evolutionary epigenomics. Ozren joined the Garvan Institute of Medical Research to lead the Developmental Epigenomics laboratory in 2017. At Garvan, Ozren is applying integrative approaches to study the contribution of the epigenome to vertebrate embryogenesis and cancer. Specifically, his research aims to unravel how a critical epigenome component, DNA methylation, participates in diverse developmental processes as well as in ageing and disease formation, and how the impaired deposition and removal of this mark impact embryonic and germline competence and integrity.
Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis. Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - Spain) where he led multiple developmental genetics projects and participated in the adaptation of next-generation sequencing technologies to vertebrate embryonic material.
In 2013 Ozren started his postdoctoral studies at the University of Western Australia where he conducted research in the field of developmental and evolutionary epigenomics. Ozren joined the Garvan Institute of Medical Research to lead the Developmental Epigenomics laboratory in 2017. At Garvan, Ozren is applying integrative approaches to study the contribution of the epigenome to vertebrate embryogenesis and cancer. Specifically, his research aims to unravel how a critical epigenome component, DNA methylation, participates in diverse developmental processes as well as in ageing and disease formation, and how the impaired deposition and removal of this mark impact embryonic and germline competence and integrity.
Awards and Honours
2019 - CINSW Career Development Fellowship
2017 - Millennium Science Award
2017 - Raine Research Prize
2016 - UWA Early Career Researcher Vice Chancellor’s Award
2013 - ARC Discovery Early Career Researcher Award (DECRA)
2013 - EMBO travel grant
2003 - IAESTE internship (FMI, Novartis)
Education
2004 – BSc / MSc (Molecular Biology) University of Zagreb - Croatia
Selected Publications
Ross SE, Angeloni A, Geng FS, de Mendoza A, Bogdanovic O. Developmental remodelling of non-CG methylation at satellite DNA repeats. Nucleic Acids Res. 2020 Dec 16;48(22):12675-12688.
Skvortsova K, Tarbashevich K, Stehling M, Lister R, Irimia M, Raz E, Bogdanovic O. Retention of paternal DNA methylome in the developing zebrafish germline. Nat Commun. 2019 Jul 11;10(1):3054. doi: 10.1038/s41467-019-10895-6.
Marlétaz F*, Firbas PN*, Maeso I*, Tena JJ*, Bogdanovic O*, Perry M*, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutiérrez È, Cañestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fernàndez J, Lister R, Lenhard B, Holland PWH, Escriva H, Gómez-Skarmeta JL, Irimia M. Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 2018 Nov 21. doi: 10.1038/s41586-018-0734-6. full text *equal contribution
Skvortsova K, Iovino N^, Bogdanović O^. Functions and mechanisms of epigenetic inheritance in animals. Nature Reviews Molecular Cell Biology. 2018 Dec;19(12):774-790 journal
Zenk F, Loeser E, Schiavo R, Kilpert F, Bogdanović O, Iovino N. Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science. 2017 Jul 14;357(6347): 212-216 journal
Bogdanović O^, Lister R^. DNA methylation and the preservation of cell identity. Current Opinion in Genetics & Development. doi: 10.1016/j.gde.2017.06.007 journal
Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016 Oct 19;538(7625):336-343 full text DNA cover art
Bogdanović O^, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M^, Gómez-Skarmeta JL^, Lister R^ (2016) Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nature Genetics. Apr;48(4):417-26 journal DNA protein
Hontelez S, van Kruijsbergen I, Georgiou G, van Heeringen SJ, Bogdanovic O, Lister R, Veenstra GJ (2015) Embryonic transcription is controlled by maternally defined chromatin state. Nature Communications. Dec 18;6:10148 full text DNA
Bogdanović O, Lister R (2015) Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs. Cell Stem Cell. May 7;16(5):459-60 full text
Bogdanović O*, Delfino-Machín M*, Nicolás-Pérez M, Gavilán MP, Gago-Rodrigues I, Fernández-Miñán A, Lillo C, Ríos RM, Wittbrodt J, Martínez-Morales JR (2012) Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis. Developmental Cell. Oct 16;23(4):782-95 full text cover art *equal contribution
Bogdanovic O, Fernandez-Miñán A, Tena JJ, de la Calle-Mustienes E, Hidalgo C, van Kruysbergen I, van Heeringen SJ, Veenstra GJ, Gómez-Skarmeta JL (2012) Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis. Genome Research Oct;22(10):2043-53 full text DNA
Bogdanović O, van Heeringen SJ, Veenstra GJ (2012) The epigenome in early vertebrate development. Genesis. Mar;50(3):192-206 full text
Bogdanovic O, Long SW, van Heeringen SJ, Brinkman AB, Gómez-Skarmeta JL, Stunnenberg HG, Jones PL, Veenstra GJ (2011) Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis. Genome Research Aug;21(8):1313-27 full text DNA
Bogdanović O, Veenstra GJ (2009) DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma. Oct;118(5):549-65 full text
Complete list of publications can be accessed here
^ corresponding author
