Dr Andy Philp

Dr Andy Philp is a group leader in the Diabetes and Metabolism Division at the Garvan Institute of Medical Research, where he leads the Mitochondrial Metabolism and Ageing laboratory. Andy completed his PhD in Exercise Physiology at the University of Brighton UK, before completing post-doctoral trai
Group Leader - Mitochondrial Metabolism and Ageing

Principal Investigator

Conjoint/Adjunct Role(s)

Senior Research Fellow, University of Birmingham, UK.

Dr Andy Philp is a group leader in the Diabetes and Metabolism Division at the Garvan Institute of Medical Research, where he leads the Mitochondrial Metabolism and Ageing laboratory. Andy completed his PhD in Exercise Physiology at the University of Brighton UK, before completing post-doctoral training at the University of Dundee and the University of California Davis. Andy set up his independent research group at the University of Birmingham UK in 2012 where he joined as a Lecturer in Integrative Physiology, progressing to Senior Lecturer before leaving in 2018. Andy has received New Investigator awards from the American Physiological Society, RANK prize nutrition funds and the Biotechnology and Biological Sciences Research Council, securing >$4 million of research funding as a principal investigator. Andy is Specialty Chief Editor for Frontiers in Nutrition and serves as an Academic Editor for PLoS One and Translational Sports Medicine.

 

Andy’s current research is focused on understanding how physiological stimuli such as exercise; inactivity and nutrition induce molecular signaling networks to remodel skeletal muscle in the context of health and disease. His group at the Garvan will explore the role of mitochondrial metabolism in the progression of muscle deterioration in Diabetes and Ageing, focusing on the therapeutic potential of exercise, pharmacology and nutraceuticals to maintain optimal muscle function across healthspan. To achieve these goals, Andy’s group utilizes cell, worm, rodent and human experimental models in combination with ‘omic’ platforms to provide detailed metabolic characterization of skeletal muscle. Andy is based on the 6th floor in the main Garvan building in office 6.01A.

Research Interests

• Skeletal muscle adaptation to exercise, inactivity and nutrition.
• The role and regulation of mitochondrial biogenesis across healthspan.
• Exercise-sensitive transduction pathways in skeletal muscle.
• Nutraceuticals as therapeutics for skeletal muscle metabolic disease.
• Bioenergetics of skeletal muscle growth and regeneration.

Awards and Honours

2015 - BBSRC New Investigator Award.
2014 - American Physiological Society Endocrinology and Metabolism New Investigator Award.
2013 - RANK Prize funds New Investigator Award.
2012 - UC Davis Award for Excellence in Postdoctoral Research.
2009 - American Physiological Society Research Recognition Award.

Education

2010 - Ph.D. Exercise Physiology | University of Brighton, UK
2002 - B.Sc. Exercise Science | University of Brighton, UK

Selected Publications

Hodson, N. Brown, T. Joanisse, S. Aguirre, N. West, DWD, Moore, DR. Baar, K. Breen, L. Philp, A. Characterisation of L-Type Amino Acid Transporter 1 (LAT1) Expression in Human Skeletal Muscle by Immunofluorescent Microscopy. Nutrients. Dec 26;10(1). pii: E23. doi: 10.3390/nu10010023, 2017.

Stocks, B. Dent, J.R. Joanisse, S. McCurdy, C. Philp, A. Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity. Front. Physiol. Dec 4;8:941. doi: 10.3389/fphys.2017.00941, 2017.

Dent, J.R. Martins, V.F. Svensson, K. LaBarge, S.A. Schlenk, N.C. Esparza, M.C. Buckner, E.H. Meyer, G.A. Hamilton, D.L. Schenk, S. Philp, A. Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. Dec;6(12):1574-1584. doi: 10.1016/j.molmet.2017.10.004, 2017.

Pérez-Schindler, J. Kanhere, A. Edwards, L. Allwood, W.L. Dunn, W.B. Schenk, S. Philp, A. Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle. Scientific Reports. Oct 18;7(1):13485. doi: 10.1038/s41598-017-14081-w, 2017.

Wilkinson, D.J. Hossain, T. Limb, M.C. Phillips, B.E. Lund, J. Williams, J.P. Brook, M.S. Cegielski, J. Philp, A. Ashcroft, S. Rathmacher, J.A. Szewczyk, N.J. Smith, K. Atherton, P.J. Impact of the calcium form of b-hydroxy-b-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition. Oct 6. pii: S0261-5614(17)31356-0, 2017.

Hodson, H. McGlory, C. Oikawa, S,Y. Jeromson, S. Song, Z. Rüegg, M,A. Hamilton, D,L. Phillips, S,M. Philp, A. Differential localisation and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise. Am J Physiol Cell Physiol. Dec 1;313(6):C604-C611, 2017.

Pérez-Schindler, J. Esparza, M. McKendry, J. Breen, L. Philp, A. Schenk, S. Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3. Am J Physiol Cell Physiol. Jun 28:ajpcell.00100.2017, 2017.

Accompanying editorial focus: http://www.physiology.org/doi/10.1152/ajpcell.00165.2017

Song, S. Moore, DR. Hodson, N. Ward, C. Dent, JR. O’Leary, MF. Shaw, AM. Hamilton, DL. Sarkar, S. Gangloff, Y-G. Hornberger, TA. Spriet, LL. Heigenhauser, GJ. Philp, A. Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. Scientific Reports, Jul 10;7(1):5028. doi: 10.1038/s41598-017-05483-x, 2017.

Elhassan, YS. Philp, A. Lavery, GG. Targeting NAD+ in metabolic disease; new insights into an old molecule. Journal of the Endocrine Society, js.2017-00092, 10.1210/js.2017-00092, 2017.

Jeromson, S. Mackenzie, I. Doherty, M. Whitfield, P. Bell, G. Dick, J. Shaw, A. Rao, F. Ashcroft, S. Philp, A. Galloway, S. Gallagher, I. Hamilton, DL. Lipid remodelling and an altered membrane proteome may drive the effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion. Am J Physiol Endocrinol Metab. Jun 27:ajpendo004382015. doi: 10.1152/ajpendo.00438.2015, 2017.

Fletcher, RS. Ratajczak, J. Doig, CL. Oakey, LA. Callingham, R. Xavier, GDS. Garten, A. Elhassan, YS. Redpath, P. Migaud, ME. Philp, A. Brenner, C. Canto, C. Lavery, GG. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol. Metab. May 29;6(8):819-832, 2017.

Jackman, SR. Witard, OC. Philp, A. Wallis, GA. Baar, K. Tipton, KD. Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans. Front. Physiol. | doi: 10.3389/fphys.2017.00390, 2017.

Park,S-J. Gavrilova, O. Brown, AL. Soto, JE. Bremner, S. Kim, J. Xu, X. Yang, S. Um, J-H. Koch, LG. Britton, SL. Lieber, RL. Philp, A. Baar, K. Kohama, SG. Abel, DE. Kim, MK. Chung, JH. DNA-PK promotes the mitochondrial, metabolic and physical decline that occurs during aging. Cell Metab. Aug 1;26(2):447. doi: 10.1016/j.cmet.2017.07.005, 2017.

Park, S-J. Ahmad, F. Um, J-H. Brown, AL. Xu, X. Kang, H. Ke, H. Feng, X. Ryall, J. Philp, A. Schenk, S. Kim, MK. Sartorelli, V. Chung, JH. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. doi: 10.1016/j.ebiom. 2017.03.019, 2017.

Doig, CL. Fletcher, RS. Morgan, SA. McCabe, EL. Tomlinson, JW. Stewart, PM. Philp, A. Lavery, GG. 11β-HSD1 determines the set-point of brown adipose tissue response to glucocorticoids. Endocrinology. Jun 1;158(6):1964-1976, 2017.