Dr Brooke Pereira

Research Officer - Invasion and Metastasis Lab

Dr Brooke Pereira

Brooke completed her PhD at Monash University within the Biomedicine Discovery Institute (BDI) under the supervision of Professor Gail Risbridger in late 2018. During her candidature she studied tumour-stroma interactions in localised prostate cancer using tissue engineering and quantitative mass sp

Research Level

Research Officer

Biography

Brooke completed her PhD at Monash University within the Biomedicine Discovery Institute (BDI) under the supervision of Professor Gail Risbridger in late 2018. During her candidature she studied tumour-stroma interactions in localised prostate cancer using tissue engineering and quantitative mass spectrometry (MS)-based proteomics. Brooke is now a post-doctoral Research Officer at the Garvan Institute of Medical Research, where she is investigating novel stromal targets in pancreatic cancer under the supervision of Associate Professor Paul Timpson. She is using a range of cutting-edge techniques such as patient-derived xenografting (PDX), LC-MS/MS, MALDI imaging and advanced microscopy to study the stroma of both murine and human pancreatic tumours.

Brooke completed her PhD at Monash University within the Biomedicine Discovery Institute (BDI) under the supervision of Professor Gail Risbridger in late 2018. During her candidature she studied tumour-stroma interactions in localised prostate cancer using tissue engineering and quantitative mass spectrometry (MS)-based proteomics. Brooke is now a post-doctoral Research Officer at the Garvan Institute of Medical Research, where she is investigating novel stromal targets in pancreatic cancer under the supervision of Associate Professor Paul Timpson. She is using a range of cutting-edge techniques such as patient-derived xenografting (PDX), LC-MS/MS, MALDI imaging and advanced microscopy to study the stroma of both murine and human pancreatic tumours.

Awards and Honours

AWARDS/HONOURS
2018 Lorne Cancer Conference Poster Prize – 1 of 6 awarded
2017 EACR Image of the Month – “3D melt electrospun scaffold model of the human prostate tumour microenvironment” http://magazine.eacr.org/eacr-image-of-the-month-october-2016-2017/4/
2016 World Biomaterials Congress (WBC) Trainee Award – 1 of 45 recipients worldwide
2014 ASMR Campion-Ma-Playoust Memorial Award – Best Presentation at the Australian Health and Medical Research Congress
2014 Department of Education Research Training Program (RTP) PhD Stipend
2013 Monash Summer Research Scholarship – Australian Centre of Blood Diseases (ACBD)

TRAVEL GRANTS
2017 ESA Postgraduate Student Travel Grant
2017 ASBTE Postgraduate Student Travel Grant
2016 Monash University Postgraduate Travel Grant Award
2016 ASBTE Postgraduate Student Travel Grant
2015 Monash Institute for Medical Engineering (MIME) Travel Grant
2014 Justus Liebig University (JLU) Postgraduate Student Travel Grant

Education

PhD - 2018 - Monash University Australia
BS/BEng (Hons) - 2013 - Monash University Australia

Selected Publications

Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian  A, Grey S, Silva AD, Leung W, Australian Pancreatic Genome Initiative (APGI)*, Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips, PA, Whitelock, JM, Gill AJ., Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR & Timpson P (2019) “CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan”. Nature Communications, 10(1): p. 3637.

*Pereira BA as a member of the APGI

EV Nguyen*, BA Pereira*, MG Lawrence, RJ Rebello, H Chan, B Niranjan, JN Skhinas, TR Cox, GP Risbridger, RA Taylor^, NL Lister^ & Roger J. Daly^ (2019) “Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment”. Molecular & Cellular Proteomics, mcp.RA119.001496. (^,* contributed equally)

BA Pereira, K Hashimoto, NL Lister, L Teng, M Flandes-Iparraguirre, A Eder, A Sanchez-Herrero, B Niranjan, Melbourne Urological Research Alliance (MURAL), M Frydenberg, MM Papargiris, MG Lawrence, RA Taylor, DW Hutmacher, SJ Ellem*, GP Risbridger*, EM De-Juan-Pardo* (2019) “Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro”. Biomaterials 197:72-85. (* contributed equally)

BA Pereira, NL Lister, EM De-Juan-Pardo, GP Risbridger & SJ Ellem (2017). 5.17 Three-Dimensional Bioengineered Cancer Models Comprehensive Biomaterials (2nd Edition). Oxford, Elsevier: 303-328.

DW Hutmacher, BM Holzapfel, EM De-Juan-Pardo, BA Pereira, SJ Ellem, D Loessner and GP Risbridger (2015). "Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance." Current Opinion in Biotechnology 35(0):127-132.

B Kolodziejczyk, O Winther-Jensen, BA Pereira, SS Nair and B Winther-Jensen (2015). "Patterning of conducting layers on breathable substrates using laser engraving for gas sensors." Journal of Applied Polymer Science 132: 42359.