Ozren Bogdanovic

Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis in the lab of Gert Jan Veenstra. Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - S
Lab Head-Developmental Epigenomics

Senior Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney

Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis in the lab of Gert Jan Veenstra.

Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - Spain) to work with Jose Luis Gomez-Skarmeta and Juan Ramon Martinez-Morales on various aspects of embryonic gene regulation. There he led a number of developmental genetics projects and participated in the adaptation of next-generation sequencing technologies to vertebrate embryonic material.

In 2013 Ozren started his postdoctoral studies at the University of Western Australia in the laboratory of Ryan Lister where he conducted research in the field of developmental and evolutionary epigenomics. His work at UWA includes the discovery of a highly conserved epigenome remodeling event associated with vertebrate body plan formation. Ozren joined the Garvan Institute of Medical Research as a Lab Head in February 2017. At the Garvan Ozren is applying integrative approaches to study the contribution of the epigenome to vertebrate embryogenesis and cancer formation.

Research Interests

DNA methylation
Embryogenesis
Epigenetics
Bioinformatics
Gene expression
Developmental Biology

Awards and Honours

2017 - Millennium Science Award
2017 - Raine Research Prize
2016 - UWA Early Career Researcher Vice Chancellor’s Award
2016 - UWA Research Collaboration Award
2015 - UWA Research Collaboration Award
2014 - ECR Award to attend the annual meeting of the Australian Academy of Sciences
2014 - Cell Symposia – Transcriptional Regulation in Development, Poster Presentation Award
2013 - ARC Discovery Early Career Researcher Award (DECRA)
2013 - EMBO travel grant
2003 - IAESTE internship to work at Friedrich Miescher Institute (Basel, CH)

Education

2012 – PhD (Molecular Biology) Radboud University Nijmegen - the Netherlands
2004 – BSc / MSc (Molecular Biology) University of Zagreb - Croatia

Selected Publications

Marlétaz F*, Firbas PN*, Maeso I*, Tena JJ*, Bogdanovic O*, Perry M*, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutiérrez È, Cañestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fernàndez J, Lister R, Lenhard B, Holland PWH, Escriva H, Gómez-Skarmeta JL, Irimia M. Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 2018 Nov 21. doi: 10.1038/s41586-018-0734-6. full text  *equal contribution

Skvortsova K, Iovino N^, Bogdanović O^. Functions and mechanisms of epigenetic inheritance in animals. Nature  Reviews Molecular Cell Biology. 2018 Dec;19(12):774-790 journal 

Zenk F, Loeser E, Schiavo R, Kilpert F, Bogdanović O, Iovino N. Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science2017 Jul 14;357(6347): 212-216 journal

Bogdanović O^, Lister R^. DNA methylation and the preservation of cell identity. Current Opinion in Genetics & Development. doi: 10.1016/j.gde.2017.06.007 journal

Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016 Oct 19;538(7625):336-343 full text  DNA  cover art

Bogdanović O^, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M^, Gómez-Skarmeta JL^, Lister R^ (2016) Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nature Genetics. Apr;48(4):417-26  journal  DNA  protein

Hontelez S, van Kruijsbergen I, Georgiou G, van Heeringen SJ, Bogdanovic O, Lister R, Veenstra GJ (2015) Embryonic transcription is controlled by maternally defined chromatin state. Nature Communications. Dec 18;6:10148 full text  DNA

Bogdanović O, Lister R (2015) Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs. Cell Stem Cell. May 7;16(5):459-60 full text

Bogdanović O*, Delfino-Machín M*, Nicolás-Pérez M, Gavilán MP, Gago-Rodrigues I, Fernández-Miñán A, Lillo C, Ríos RM, Wittbrodt J, Martínez-Morales JR (2012) Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis. Developmental Cell. Oct 16;23(4):782-95 full text  cover art  *equal contribution

Bogdanovic O, Fernandez-Miñán A, Tena JJ, de la Calle-Mustienes E, Hidalgo C, van Kruysbergen I, van Heeringen SJ, Veenstra GJ, Gómez-Skarmeta JL (2012) Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis. Genome Research Oct;22(10):2043-53  fulltext  DNA

Bogdanović O, van Heeringen SJ, Veenstra GJ (2012) The epigenome in early vertebrate development. Genesis. Mar;50(3):192-206 full text

Bogdanovic O, Long SW, van Heeringen SJ, Brinkman AB, Gómez-Skarmeta JL, Stunnenberg HG, Jones PL, Veenstra GJ (2011) Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis. Genome Research Aug;21(8):1313-27 full text  DNA

Bogdanović O, Veenstra GJ (2009) DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma. Oct;118(5):549-65 full text

Complete list of publications can be accessed here

^ corresponding author

 

Person portrait

Ozren Bogdanovic

Research group