Ozren Bogdanovic

Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis in the lab of Gert Jan Veenstra. Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - S
Lab Head-Developmental Epigenomics

Senior Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney

Ozren Bogdanovic obtained his PhD from Radboud University (Nijmegen, the Netherlands), where he worked on DNA methylation and methyl CpG-binding proteins during early embryogenesis in the lab of Gert Jan Veenstra.

Ozren then moved to the Andalusian Centre for Developmental Biology (CABD, Seville - Spain) to work with Jose Luis Gomez-Skarmeta and Juan Ramon Martinez-Morales on various aspects of embryonic gene regulation. There he led a number of developmental genetics projects and participated in the adaptation of next-generation sequencing technologies to vertebrate embryonic material.

In 2013 Ozren started his postdoctoral studies at the University of Western Australia in the laboratory of Ryan Lister where he conducted research in the field of developmental and evolutionary epigenomics. His work at UWA includes the discovery of a highly conserved epigenome remodeling event associated with vertebrate body plan formation. Ozren joined the Garvan Institute of Medical Research as a Lab Head in February 2017. At the Garvan Ozren is applying integrative approaches to study the contribution of the epigenome to vertebrate embryogenesis and cancer formation.

Research Interests

DNA methylation
Gene expression
Developmental Biology

Awards and Honours

2017 - Millennium Science Award
2017 - Raine Research Prize
2016 - UWA Early Career Researcher Vice Chancellor’s Award
2016 - UWA Research Collaboration Award
2015 - UWA Research Collaboration Award
2014 - ECR Award to attend the annual meeting of the Australian Academy of Sciences
2014 - Cell Symposia – Transcriptional Regulation in Development, Poster Presentation Award
2013 - ARC Discovery Early Career Researcher Award (DECRA)
2013 - EMBO travel grant
2003 - IAESTE internship to work at Friedrich Miescher Institute (Basel, CH)


2012 – PhD (Molecular Biology) Radboud University Nijmegen - the Netherlands
2004 – BSc / MSc (Molecular Biology) University of Zagreb - Croatia

Selected Publications


Ford E, Grimmer MR, Stolzenburg S, Bogdanovic O, de Mendoza A, Farnham PJ, Blancafort P, Lister R. Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation. bioRxiv doi: https://doi.org/10.1101/17050.  full text

Journal Articles

Elurbe DM, Paranjpe SS, Georgiou G, van Kruijsbergen I, Bogdanovic O, Gibeaux R, Heald R, Lister R, Huynen MA, van Heeringen SJ, Veenstra GJC. Regulatory remodeling in the allo-tetraploid frog Xenopus laevis. Genome Biol. 2017 Oct 24;18(1):198. full text

Zenk F, Loeser E, Schiavo R, Kilpert F, Bogdanović O, Iovino N. Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science2017 Jul 14;357(6347): 212-216 journal

Bogdanović O^, Lister R^. DNA methylation and the preservation of cell identity. Curr Opin Genet Dev. doi: 10.1016/j.gde.2017.06.007 journal

Bogdanović O^. Tet proteins: master regulators of vertebrate body plan formation? Epigenomics. 2017 Feb;9(2):93-96 full text

Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016 Oct 19;538(7625):336-343 full text  DNA  cover art

Bogdanovic O, van Heeringen SJ. ChIP-seq Data Processing for PcG Proteins and Associated Histone Modifications. Methods Mol Biol. 2016;1480:37-53 journal

Bogdanović O^, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M^, Gómez-Skarmeta JL^, Lister R^ (2016) Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nature Genetics. Apr;48(4):417-26  journal  DNA  protein

de la Calle Mustienes E, Gómez-Skarmeta JL, Bogdanović O^ (2015) Genome-wide epigenetic cross-talk between DNA methylation and H3K27me3 in zebrafish embryos. Genomics Data. Jul 22;6:7-9 full text  DNA

Hontelez S, van Kruijsbergen I, Georgiou G, van Heeringen SJ, Bogdanovic O, Lister R, Veenstra GJ (2015) Embryonic transcription is controlled by maternally defined chromatin state. Nature Communications. Dec 18;6:10148 full text  DNA

Bogdanović O, Lister R (2015) Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs. Cell Stem Cell. May 7;16(5):459-60 full text

Bogdanović O*, Fernández-Miñán A*, Tena JJ*, de la Calle-Mustienes E, Gómez-Skarmeta JL (2013) The developmental epigenomics toolbox: ChIP-seq and MethylCap-seq profiling of early zebrafish embryos. Methods. Aug 15;62(3):207-15 journal  DNA

Bogdanović O*, Delfino-Machín M*, Nicolás-Pérez M, Gavilán MP, Gago-Rodrigues I, Fernández-Miñán A, Lillo C, Ríos RM, Wittbrodt J, Martínez-Morales JR (2012) Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis. Developmental Cell. Oct 16;23(4):782-95 full text  cover art

Bogdanović O (2012) DNA methylation and methyl-CpG binding proteins during early development. ISBN: 978-94-6182-087-7 full text

Bogdanovic O, Fernandez-Miñán A, Tena JJ, de la Calle-Mustienes E, Hidalgo C, van Kruysbergen I, van Heeringen SJ, Veenstra GJ, Gómez-Skarmeta JL (2012) Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis. Genome ResearchOct;22(10):2043-53 fulltext  DNA

Bogdanović O, van Heeringen SJ, Veenstra GJ (2012) The epigenome in early vertebrate development. Genesis. Mar;50(3):192-206 full text

Bogdanovic O, Long SW, van Heeringen SJ, Brinkman AB, Gómez-Skarmeta JL, Stunnenberg HG, Jones PL, Veenstra GJ (2011) Temporal uncoupling of the DNA methylome and transcriptional repression during embryogenesis. Genome ResearchAug;21(8):1313-27 full text  DNA

Bogdanović O, Veenstra GJ (2009) DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma. Oct;118(5):549-65 full text

Complete list of publications can be accessed here

^ corresponding author

* equal contribution

Person portrait

Ozren Bogdanovic

Research group