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Professor Tri Phan

Role
Program Director - Precision Immunology / Laboratory Head - Intravital Microscopy
Lab/Group
Intravital Microscopy and Gene Expression (IMAGE) Lab

Professor Tri Phan studied undergraduate medicine at the University of Sydney and completed a double fellowship in Internal Medicine and Pathology under the guidance Dr Stephen Adelstein and Dr Roger Garsia in the Department of Clinical Immunology at the Royal Prince Alfred Hospital, Sydney. For his PhD he developed a B cell receptor knock-in mouse model to study in vivo B cell responses to foreign and self-antigen under the supervision of Professor Antony Basten and Associate Professor Robert Brink at the Centenary Institute, Sydney.

His interest in defining the in vivo contexts of B cell responses and resolving germinal centre selection events in space and time lead to post-doctoral studies with Professor Jason Cyster at the Howard Hughes Medical Institute, University of California, San Francisco where he used intravital two-photon microscopy to investigate the initiation of B cell responses in the lymph node. Tri established an intravital two-photon microscope facility at the Garvan Institute in 2010.

Awards

  • 2018NHMRC Senior Research Fellowship
  • 2017SVH Consultant Tutor of the Year
  • 2014ANSTO Eureka Prize for Innovative Use of Technology
  • 2011NHMRC Career Development Fellowship
  • 2006American Australian Association Sir Keith Murdoch Fellowship
  • 2006NHMRC C.J. Martin Post-doctoral Research Fellowship
  • 2005Australasian Society of Immunology New Investigator Award
  • 2005University of Sydney Early Career Development Award
  • 1999D.S. Nelson Prize (Royal College of Pathologists of Australasia)
  • 1998Eddie Hirst Memorial Prize (Royal College of Pathologists of Australasia)
  • 1994University Medal - University of Sydney

Selected publications

See all publications
  • 2025
    Cell10.1016/j.cell.2025.04.005

    Macrophages direct location-dependent recall of B cell memory to vaccination.

    Rama Dhenni, Alexandra Carey Hoppé, Arnold Reynaldi, Wunna Kyaw, Nathalie Tricia Handoko, Abigail K Grootveld, Yuki Honda Keith, Nayan Deger Bhattacharyya, Holly I Ahel, Aiden Josiah Telfser, Andrew N McCorkindale, Seyhan Yazar, Christina H T Bui, James T Smith, Weng Hua Khoo, Mollie Boyd, Solange Obeid, Brad Milner, Mitchell Starr, Fabienne Brilot, Vanessa Milogiannakis, Anouschka Akerman, Anupriya Aggarwal, Miles P Davenport, Elissa K Deenick, Christine L Chaffer, Peter I Croucher, Robert Brink, Leonard D Goldstein, Deborah Cromer, Stuart G Turville, Anthony D Kelleher, Vanessa Venturi, C Mee Ling Munier, Tri Giang Phan
  • 2023
    Cell10.1016/j.cell.2023.02.004

    Apoptotic cell fragments locally activate tingible body macrophages in the germinal center.

    Abigail K Grootveld, Wunna Kyaw, Veera Panova, Angelica W Y Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A Hume, Peter I Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
  • 2021
    Cell10.1016/j.cell.2021.02.002

    Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

    Michelle M McDonald, Weng Hua Khoo, Pei Ying Ng, Ya Xiao, Jad Zamerli, Peter Thatcher, Wunna Kyaw, Karrnan Pathmanandavel, Abigail K Grootveld, Imogen Moran, Danyal Butt, Akira Nguyen, Alexander Corr, Sean Warren, Maté Biro, Natalie C Butterfield, Siobhan E Guilfoyle, Davide Komla-Ebri, Michael R G Dack, Hannah F Dewhurst, John G Logan, Yongxiao Li, Sindhu T Mohanty, Niall Byrne, Rachael L Terry, Marija K Simic, Ryan Chai, Julian M W Quinn, Scott E Youlten, Jessica A Pettitt, David Abi-Hanna, Rohit Jain, Wolfgang Weninger, Mischa Lundberg, Shuting Sun, Frank H Ebetino, Paul Timpson, Woei Ming Lee, Paul A Baldock, Michael J Rogers, Robert Brink, Graham R Williams, J H Duncan Bassett, John P Kemp, Nathan J Pavlos, Peter I Croucher, Tri Giang Phan