A/Prof Yanchuan Shi

Group Leader - Neuroendocrinology Group

A/Prof Yanchuan Shi

A/Prof Yanchuan (Yan) Shi obtained her Bachelor’s degree in Medicine followed by a Masters' degree in Nutrition. She worked full time as a Lecturer/Senior Lecturer at Tianjin Medical University. In 2001, she was awarded a competitive WHO fellowship to conduct a one-year research project in osteoporo

Biography

A/Prof Yanchuan (Yan) Shi obtained her Bachelor’s degree in Medicine followed by a Masters' degree in Nutrition. She worked full time as a Lecturer/Senior Lecturer at Tianjin Medical University. In 2001, she was awarded a competitive WHO fellowship to conduct a one-year research project in osteoporosis within the Division of Clinical Biochemistry/Department of Endocrinology, IMVS/Royal Adelaide Hospital. After being awarded an International Postgraduate Research Scholarship (IPRS), she commenced her PhD at UNSW Australia in 2002, investigating the responses of bone cells to the activation of the Wnt signaling pathway and vitamin D.

She received her PhD degree in Medicine in 2006 and moved to the Neuroscience Division at the Garvan Institute, starting her postdoc training at the Eating Disorder Research Lab. In February 2012, she received the Australian Medical Council (AMC) Certificate after successfully re-qualifying for her Australian medical license, allowing her to practice medicine in Australia. She was promoted to Group Leader of the Neuroendocrinology Group in 2014, leading her independent research.

As a clinician scientist with medical qualification recognised in both Australia and China, she has a unique set of strengths in research, in translation and in collaboration. Since 2007, she has authored 41 peer-reviewed publications in top-ranked journals including Cell Metabolism, Nature Communications, Diabetes, eLifeMolecular Metabolism, EndocrinologyTrends in Endocrinology and Metabolism, and Obesity. She has been invited to speak or present at many international, national and local conferences. Her standing in energy/glucose metabolism and NPY research has allowed the establishment of collaborations within or outside her research field. Her research has been funded by the National Health Medical Research Council (NHMRC) project grants and the Diabetes Australia (DART) grants. 

She has also demonstrated a strong commitment to research supervision and mentoring. Since 2009, she has supervised/mentored more than 20 research individuals including PhD students, Honours, research undergraduates, junior postdocs, overseas research interns and junior research staff. She is currently recruiting PhD students and Honours students to conduct fully-funded research projects. Visiting scholars and undergraduate Research Opportunity Program (UROP) students are also welcome.

A/Prof Yanchuan (Yan) Shi obtained her Bachelor’s degree in Medicine followed by a Masters' degree in Nutrition. She worked full time as a Lecturer/Senior Lecturer at Tianjin Medical University. In 2001, she was awarded a competitive WHO fellowship to conduct a one-year research project in osteoporosis within the Division of Clinical Biochemistry/Department of Endocrinology, IMVS/Royal Adelaide Hospital. After being awarded an International Postgraduate Research Scholarship (IPRS), she commenced her PhD at UNSW Australia in 2002, investigating the responses of bone cells to the activation of the Wnt signaling pathway and vitamin D.

She received her PhD degree in Medicine in 2006 and moved to the Neuroscience Division at the Garvan Institute, starting her postdoc training at the Eating Disorder Research Lab. In February 2012, she received the Australian Medical Council (AMC) Certificate after successfully re-qualifying for her Australian medical license, allowing her to practice medicine in Australia. She was promoted to Group Leader of the Neuroendocrinology Group in 2014, leading her independent research.

As a clinician scientist with medical qualification recognised in both Australia and China, she has a unique set of strengths in research, in translation and in collaboration. Since 2007, she has authored 41 peer-reviewed publications in top-ranked journals including Cell Metabolism, Nature Communications, Diabetes, eLifeMolecular Metabolism, EndocrinologyTrends in Endocrinology and Metabolism, and Obesity. She has been invited to speak or present at many international, national and local conferences. Her standing in energy/glucose metabolism and NPY research has allowed the establishment of collaborations within or outside her research field. Her research has been funded by the National Health Medical Research Council (NHMRC) project grants and the Diabetes Australia (DART) grants. 

She has also demonstrated a strong commitment to research supervision and mentoring. Since 2009, she has supervised/mentored more than 20 research individuals including PhD students, Honours, research undergraduates, junior postdocs, overseas research interns and junior research staff. She is currently recruiting PhD students and Honours students to conduct fully-funded research projects. Visiting scholars and undergraduate Research Opportunity Program (UROP) students are also welcome.

Awards and Honours

2017 - Research Excellence Award, Australian Association of Chinese Biomedical Scientists, Australia
2005 - Travel Grant, 15th Annual Meeting of the Australian and New Zealand Bone and Mineral Society (ANZBMS), Perth, WA, Australia
2002-2005 - International Postgraduate Research Scholarship (IPRS), University of New South Wales, Australia
2001-2002 - WHO Fellowship, one of 43 winners selected from all over China, World Health Organization

Education

AMC Certificate. Australian Medical Council (AMC)
PhD. University of New South Wales
Master's degree in Nutrition. Harbin Medical University
Bachelor's degree in Medicine. Harbin Medical University

Fundings

-- Diabetes Australia DART project grant, 2020: sole CI (Chief Investigator) (Category 1 funder)

-- National Health Medical Research Council (NHMRC) project grant, 2019-2021: sole CI 

-- Diabetes Australia DART project grant, 2019: sole CI

-- National Health Medical Research Council (NHMRC) project grant, 2018-2020: CIA (Chief Investigator A)

-- Diabetes Australia (DART) general grant, 2017: sole CI 

-- China Diabetes Young Scientific Talent Research Project Grant, 2018: CIB

-- Bureau of Foreign Experts Affairs (BFEA) Grant, China, 2018: CIB

 

Selected Publications

2021

Zhang Y, Liu C, Chen WC, Shi YC, Wang C, Lin S, He H. Regulation of Neuropeptide Y in body microenvironments and its potential application in therapies: A review. Cell & Bioscience. Aug 3

Yan C, Zeng T, Lee K, Nobis M, Loh K, Gou L, Xia Z, Gao Z, Bensellam M, Hughes MW, Lau J, Zhang L, Ip CK, Enriquez R, Gao H, Wang QP, Wu Q, Haigh JJ, Laybutt DR, Timpson P, Herzog H, Shi YC. Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. Nature Communications.  May 11

Zhao YX, Chen SR, Huang Q, Chen WC, Xia T, Shi YC, Gao H, Shi QY, Lin S. Repair abilities of mouse autologous adipose-derived stem cells and ShakeGelTM3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation. The Stem Cell Research & Therapy. March 18

2020

Hu X, Zhou J, Song S, Kong W, Shi YC, Chen LL, Zeng TS. TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis. Mediators of Inflammation. Sept 16

Wu WQ, Peng S, Shi YC, Song ZY, Lin S. NPY promotes macrophage migration by up-regulating matrix metalloproteinase-8 expression. Journal of Cellular Physiology. July 24

Wang QP, Lin YQ, Lai ML, Su Z, Oyston LJ, Clark T, Park SJ, Khuong TM, Lau MT, Shenton V, Shi YC, James DE, Ja WW, Herzog H, Simpson SJ, Neely GG. PGC1 alpha controls sucrose taste sensitization in Drosophila. Cell Reports. April

2019

Wan XQ, Zeng F, Huang XF, Yang HQ, Wang L, Shi YC, Zhang ZH, Lin S. Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor – NPY pathways. CNS Neuroscience & Therapeutics. Dec 21

Zhao YX, Chen SR, Su PP, Huang FH, Shi YC, Shi QY, Lin S. Using mesenchymal stem cells to treat female infertility: an update on female reproductive diseases. Stem Cells International. Dec 6

Bensellam M, Shi YC, Chan JY, Laybutt DR, Chae H, Abou-Samra M, Pappas EG, Thomas HE, Gilon P and Jonas J-C. Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta-cell compensation and failure. Diabetologia. Dec

Yilan Liu, Jing Yu, Shi YC, Yi Zhang, Shu Lin. The role of inflammation and endoplasmic reticulum stress in obesity related cognitive impairment. Life Sciences. Aug

Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Lee N, Bruning J, Gopalasingam G, Koller J, Hernandez-Sanchez D, Tasan R, Sperk G, Herzog H. Amygdala NPY circuits promote the development of obesity under chronic stress conditions.  Cell Metabolism. July

2018

Loh K, Shi YC, Bensellam M, Lee K, Laybutt DR, Herzog H. Y1 receptor deficiency in betake-cells leads to increased adiposity and impaired glucose metabolism. Scientific Reports. Sep

Farzi A, Lau J, Ip CK, Qi Y, Shi YC, Zhang L, Tasan R, Sperk G, Herzog H. Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure. Elife. Aug 

Lau J, Farzi A, Qi Y, Heilbronn R, Mietzsch M, Shi YC*, Herzog H*. CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis. Molecular Metabolism. Jan  (*Co-senior author)

2017

Loh K#, Shi YC#, Walters S#, Bensellam M ,Lee K, Dezaki K, Nakata M, Ip CK, Chan J, Gurzov EN, Thomas HE, Waibei M, Cantley J, Kay TM, Yada T, Laybutt DR, Grey S and Herzog H. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications. Sep (# Co-first author)

Lau J, Farzi A, Enriquez RF, Shi YC*, Herzog H*. GPR88 is a critical regulator of feeding and body composition in mice. Scientific Reports. July (*Co-senior author)

Shi YC*, Ip CK, Reed F, Sarruf DA, Wulff BS, Herzog H. Y5 receptor signalling counteracts the anorectic effects of PYY3-36 in diet-induced obese mice. J Neuroendocrinol. May (*Corresponding author)

Sun WW, Li LY, Huang XF, Shi YC, Yang HQ, Song ZY, Lin S. The central mechanism of risperidone-induced hyperprolactinemia. Progress in Neuropsychopharmacol Biol Psychiatry March

2016

Worton LE, Shi YC, Smith E, Barry S, Gonda T, Whitehead J, Gardiner EM. Ectodermal-neural cortex 1 isoforms have contrasting effects on MC3T3-E1 osteoblast mineralization and gene expression. J Cellular Biochemistry. Dec 

Lau J, Shi YC*, Herzog H*. Temperature dependence of the control of energy homeostasis requires CART signaling. Neuropeptides. April (*Co-senior author)

Seimon RV, Shi YC, Slack K, Lee K, Fernando HA, Nguyen AD, Zhang L, Lin S, Enriquez RF, Lau J, Herzog H, Sainsbury A. Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice. PLoS One. January

2015

Shi YC*, Loh K, Bensellam M, Lee K, Zhai L, Lau J, Cantley J, Luzuriaga J, Laybutt DR, Herzog H. Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice. Endocrinology. Sep (*Corresponding author)

Loh K, Herzog H*, Shi YC*. Regulation of energy homeostasis by the NPY system. Trends Endocrinol Metab. March (*Co-senior author)

2014

Baldock PA, Lin S, Zhang L, Karl T, Shi YC, Driessler F, Zengin A, Hörmer B, Lee NJ, Wong IPL, Lin EJD, Enriquez RF, Stehrer B, During MJ, Yulyaningsih E, Zolotukhin S, Ruohonen ST, Savontaus E, Sainsbury A, Herzog H. 'Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits', Journal of Bone and Mineral Research. Oct 

Nguyen AD, Slack K, Schwarzer C, Lee NJ, Boey D, Macia L, Yulyaningsih E, Enriquez RF, Zhang L, Lin S, Shi YC, Baldock PA, Herzog H, Sainsbury A. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides. June

Yulyaningsih E; Loh K; Lin S; Lau J; Zhang L; Shi YC; Berning BA; Enriquez R; Driessler F; Macia L; Khor EC; Qi Y; Baldock P; Sainsbury A; Herzog H, 'Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice', Cell Metabolism, Jan

2013

Shi YC, Lin Z, Lau J, Zhang H, Yagi M, Kanzler I, Sainsbury A, Herzog H, Lin S. PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice. Obesity. Dec

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Castillo, L., Baldock PA, Zhang L, Sainsbury A, Herzog H & Lin S. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism. Feb

2012

Macia L, Yulyaningsih E, Bijker M, Pangon L, Nguyen AD, Lin S, Shi YC, Zhang L, Mackay F, Sainsbury A, Herzog H. Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity. Diabetes. 

Shi YC, Hämmerle C, Lee I-C, Turner N, Nguyen AD, Riepler SJ, Sainsbury A, Herzog H, Zhang L. Adult-onset PYY overexpression in mice reduces food intake and increased lipogenic capacity. Neuropeptides

Shi YC & Baldock P. Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue. Bone

2011

Shi YC, Lin S, Castillo L, Aljanova A, Enriquez RF, Nguyen AD, Baldock PA, Zhang L, Bijker MS, Macia L, Yulyaningsih E, Zhang H, Lau J, Sainsbury A, Herzog H. Peripheral-specific Y2 receptor knockdown protects mice from high-fat diet-induced obesity. Obesity. 2011

2010

Shi YC, Lin S, Wong IP, Baldock PA, Aljanova A, Enriquez RF, Castillo L, Mitchell NF, Ye JM, Zhang L, Macia L, Yulyaningsih E, Nguyen AD, Riepler SJ, Herzog H, Sainsbury A. NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS One

2009

Lin S, Shi YC, Yulyaningsih E, Aljanova A, Zhang L, Macia L, Nguyen AD, Lin EJ, During MJ, Herzog H, Sainsbury A. Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS One. 2009

2007

Shi YC, Worton L, Esteban L, Baldock P, Fong C, Eisman JA, Gardiner EM. Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation. Bone