Dr Angli Xue

Dr. Angli Xue is a Postdoc Scientist and NHMRC Investigator Fellow (EL1) in Powell Lab at the Garvan Institute of Medical Research. Angli's current research is focused on understanding the genetic regulation at the single-cell level. He is leading the TenK10K multiome project, which utilises large-scale single-cell multiomics data + whole genome sequencing to identify genetic association with chromatin accessibility and dissect the regulatory mechanisms in human circulating immune cells. The phase 2 study will curate single-cell profiling for > 50 million cells from 10,000 individuals.

Angli obtained his PhD in 2021 at The University of Queensland working with Prof. Jian Yang in the field of statistical genetics. During his PhD, he utilised statistical and computational methods to dissect the genetic architecture of human complex diseases, perform meta-analyses and integrate multi-omics data to identify associated gene loci and gene regulatory mechanisms. He conducted the largest genetic study of type 2 diabetes and highlighted three T2D-associated genes with plausible regulatory mechanisms where a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. He also co-developed a software tool (GSMR2) for evaluating the causal relationship between modifiable risk factors and complex diseases. His first-authored papers have been Highly Cited Paper and highlighted by Nature Asia-Pacific. He was awarded the DeLill Nasser Award for Professional Development in Genetics (Genetics Society of America) in recognition of his PhD work. Before moving to Australia, he completed his BSc at Zhejiang University, China in 2015.