Dr David Langley
Dr David Langley was originally trained in DNA techniques whilst studying the intricacies of bacterial DNA replication during his PhD. Whilst doing a postdoc in the US he discovered the magic of proteins, and crystallised one by accident. This piqued his interest in structural biology, and he has been attempting to crystallise proteins and solve their structures using x-ray crystallography ever since. He currently works in the Antibody Therapeutics lab at the Garvan Institute of Medical Research, where he characterises the molecular details of antibody-antigen interactions.
- 2020Genome biology10.1186/s13059-020-1940-8
Systematic functional identification of cancer multi-drug resistance genes.
- 2015The Journal of biological chemistry10.1074/jbc.M114.614842
Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies.
- 2014Proceedings of the National Academy of Sciences of the United States of America10.1073/pnas.1403182111
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.
- 2014Proceedings of the National Academy of Sciences of the United States of America10.1073/pnas.1406974111
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
- 2012Proceedings of the National Academy of Sciences of the United States of America10.1073/pnas.1202866109
General strategy for the generation of human antibody variable domains with increased aggregation resistance.