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Kendelle Murphy

Dr Kendelle Murphy

Senior Research Officer
Invasion and Metastasis Lab
Research Level
Senior Research Officer

Dr Kendelle Murphy is a Senior Research Officer in the Cancer Invasion and Metastasis Laboratory at the Garvan Institute of Medical Research. Cancer develops in a complex three-dimensional environment, where tumour cell communication with the surrounding stroma governs cancer cell behaviour. Dr Murphy uses novel state-of-the-art intravital (in vivo, ACRF INCITe Centre) imaging approaches to provide new insights into how cells behave in a physiologically relevant environment, thereby improving our understanding of disease progression, drug delivery and efficacy.

Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal disease with few treatment options. Multimodal chemotherapy regimens including gemcitabine/Abraxane and FOLFIRINOX are the current standard-of-care in the clinic, however these have limited benefits to extend survival. Focal Adhesion Kinase (FAK) is known to modulate bi-directional communication between the tumour and surrounding ECM driving disease, influencing disease progression, therapy response and the development of pro-tumorigenic fibrosis.

As a CINSW (ECR) Fellow Dr Murphy conducts research has a clear focus on clinical translation. Importantly this research led to the establishment of a Phase II clinical trial (Amplia Therapeutics Ltd, ACCENT Trial, Q3 2022), highlighting the translational and collaborative capacity of her work.


  • 2023Matrix Biology Society of Australia and New Zealand - Early Career Bob Frazer Award
  • 2023Tour de Cure Annual Grant 2023
  • 2023UNSW Seed Grant
  • 2022Cancer Institute of New South Wales - Early Career Research Fellowship (2022-2024)
  • 2022Lorne Cancer Conference (Oncology One) - Best ECR Presentation
  • 2021Matrix Biology Society of Australia and New Zealand Paper of the Month (December)
  • 2021Matrix Biology Society of Australia and New Zealand Paper of the Year
  • 2021OzMRS Ms Megan Wheeler Early Career Researcher of the Year Award
  • 2018Avner Pancreatic Cancer Foundation - Rapid Fire Young Investigator Speaker Award
  • 2017Sydney Cancer Conference - Sydney - Oral Presentation Award (Hunter Cancer Research Alliance)
  • 2015British Association for Cancer Research - Poster Prize

Selected publications

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  • 2021

    Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.

    Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, Nandini Asokan, Annick Klein, Naël Osmani, Ignacio Busnelli, François Delalande, Nicodème Paul, Sébastien Halary, Frédéric Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan André-Grégoire, Vincent Mittelheisser, Alexandre Detappe, Kendelle Murphy, Paul Timpson, Raphaël Carapito, Marcel Blot-Chabaud, Julie Gavard, Christine Carapito, Nicolas Vitale, Olivier Lefebvre, Jacky G Goetz, Vincent Hyenne