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Professor Marina Pajic

Role
Laboratory Head
Lab/Group
Pajic Lab

Professor Marina Pajic is a Snow Fellow and leader in pancreatic cancer research. Since returning from a successful postdoctoral position at the Netherlands Cancer Institute and establishing her lab at the Garvan in 2013, Professor Pajic has developed an innovative program that builds on the unique infrastructure she has generated, a wealth of integrated human cancer genomic and gene product expression profiles, complex 3D and patient-derived mouse models, rapidly evolving technologies and close clinical links, to reveal new insights into the deregulation of molecules commonly hijacked in pancreatic cancer, which drive tumour heterogeneity, metastasis and chemoresistance. Her team is using this knowledge to inform the rational design of novel, tailored treatment options for patients with pancreatic cancer.

Her research is supported by the Snow Medical Fellowship, NHMRC, Cancer Council NSW, Pankind, ACRF, Cancer Institute NSW (CINSW), Ms Jane Hemstritch, the Girgensohn Foundation and Paul Ainsworth Foundation. As a Snow Medical Fellow, Professor Pajic has established a translational research program, which includes establishment of two new trials for pancreatic cancer, based on precision-medicine principles and her discovery work, during the fellowship. With more than 100 high-quality and highly cited publications in the field (more than 30,500 citations), Professor Pajic’s contributions have been recognised by several prestigious awards including the Australian Academy of Science 2020 Ruth Stephens Gani Medal for achievements in the field of applied cancer genomics and precision medicine for pancreatic cancer and the NSW Premier’s Outstanding Cancer Research Fellow Award. She takes an active role in training emerging scientists (Honours and PhD projects). Marina engages and communicates regularly with the public through Garvan’s public events and collaborative work with major pancreatic cancer foundations.

Awards

  • 2023NHMRC Investigator Grant Level 1
  • 2021Snow Medical Research Foundation Fellowship
  • 2020Australian Academy of Science Ruth Stephens Gani Medal
  • 2019NHMRC RD Wright Biomedical Career Development Fellowship Level 2
  • 2018Lorne Genome Young Investigator Award
  • 2017Cancer Institute New South Wales (CINSW) Career Development Fellowship
  • 2017NSW Premier's Award for Outstanding Cancer Research Fellow
  • 2014Australasian Pancreatic Club (APC) Co-director; Co-organiser of annual scientific conferences
  • 2014CINSW Career Development Fellowship
  • 2013Travel Grants (CASS Foundation - Sydney Catalyst)
  • 2012Conference Awards (EACR Cancer Genomics Conference - Cambridge - UK; Australian Division of International Academy of Pathology - 38th annual scientific meeting - Australia; EACR 22nd Biennial Congress - Barcelona - Spain)
  • 2012European Association for Cancer Research (EACR) ambassador
  • 2011CINSW Early Career Development Fellowship
  • 2011Phillip Hemstritch fellowship in pancreatic cancer
  • 2003University Postgraduate Award (University of Sydney) and Children’s Cancer Institute of Australia Postgraduate Scholarship (University of New South Wales)
  • 2002Postgraduate Scholarship in Cellular Cancer Pharmacology (University of Sydney)
  • 2001University postgraduate bursary award (University of Auckland)

Selected publications

See all publications
  • 2026
    Cell Death & Disease10.1038/s41419-026-08657-6

    βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer.

    George Sharbeen, John Kokkinos, Grace Schulstad, Elvis Pandzic, Janet Youkhana, Zerong Ma, Rosa Mistica C Ignacio, Aparna S Raina, Shannon Chiang, Cyrille Boyer, Koroush S Haghighi, Matthew Gunawarman, David Goldstein, Val Gebski, Marina Pajic, Meagan E Davis, Oliver S M Arkell, Chantal Kopecky, Estrella Gonzales-Aloy, Alexander Ishak, Mert Erkan, Jennifer P Morton, Maria Kavallaris, Peter W Gunning, Edna C Hardeman, Amber Johns, Anthony J Gill, Renee M Whan, Amanda Mawson, Omali Pitiyarachchi, , Joshua A McCarroll, Phoebe A Phillips
  • 2025
    Molecular Cancer Therapeutics10.1158/1535-7163.MCT-24-0704

    Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in TFCP2 Fusion-Defined Rhabdomyosarcoma.

    Patrick Bergsma, Sean Porazinski, Aji Istadi, Diego Chacon-Fajardo, Yasir Mahmood, Silvia Lombardi, Diana Schuhmacher, Henry Barraclough-Franks, Dario Strbenac, Claude V Dennis, Payam Faizi-Sobbi, Emer Cahill, Vivek A Bhadri, Jeneffer De Almeida Silva, Trina Lum, James Wykes, Timothy Manzie, Carsten E Palme, Jean Y H Yang, Jonathan R Clark, Ruta Gupta, Marina Pajic
  • 2025
    Signal Transduction and Targeted Therapy10.1038/s41392-025-02232-9

    Oncogenic proteome of pancreatic cancer extracellular vesicles: sodium/myo-inositol cotransporter as a potential marker.

    Arunima Panda, Krish Ragunath, Marina Pajic, David W Greening, Marco Falasca
  • 2025
    Cellular Signalling10.1016/j.cellsig.2025.111775

    Oncogenic small extracellular vesicles enriched in sphingosine-1-phosphate play a crucial role in pancreatic cancer progression.

    Pratibha Malhotra, Jordan Fyfe, Aikaterini Emmanouilidi, Ilaria Casari, Natalie A Mellett, Kevin Huynh, Marina Pajic, David W Greening, Peter J Meikle, Marco Falasca
  • 2025
    Science Advances10.1126/sciadv.adq4416

    Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.

    Cecilia R Chambers, Supitchaya Watakul, Peter Schofield, Anna E Howell, Jessie Zhu, Alice M H Tran, Nadia Kuepper, Daniel A Reed, Kendelle J Murphy, Lily M Channon, Brooke A Pereira, Victoria M Tyma, Victoria Lee, Michael Trpceski, Jake Henry, Pauline Melenec, Lea Abdulkhalek, Max Nobis, Xanthe L Metcalf, Shona Ritchie, Antonia Cadell, Janett Stoehr, Astrid Magenau, Diego Chacon-Fajardo, Jessica L Chitty, Savannah O'Connell, Anaiis Zaratzian, Michael Tayao, Andrew Da Silva, Ruth J Lyons, Leonard D Goldstein, Ashleigh Dale, Alexander Rookyard, Angela Connolly, Ben Crossett, Yen T H Tran, Peter Kaltzis, Claire Vennin, Marija Dinevska, , , David R Croucher, Jaswinder Samra, Anubhav Mittal, Robert J Weatheritt, Andrew Philp, Gonzalo Del Monte-Nieto, Lei Zhang, Ronaldo F Enriquez, Thomas R Cox, Yan-Chuan C Shi, Mark Pinese, Nicola Waddell, Hao-Wen Sim, Tatyana Chtanova, Yingxiao Wang, Anthony M Joshua, Lorraine Chantrill, Thomas R Jeffry Evans, Anthony J Gill, Jennifer P Morton, Marina Pajic, Daniel Christ, Herbert Herzog, Paul Timpson, David Herrmann