
Professor Paul Timpson
Professor Paul Timpson completed his PhD with Professor Margaret Frame at the Beatson Institute for Cancer Research, UK in 2002 where he assessed the interplay between Src family kinases and the actin cytoskeleton during cancer cell invasion, focusing on the role of Rho family GTPases. He then moved to the Garvan Institute of Medical Research in 2003 to work with Professor Roger Daly investigating the role of the actin-binding protein cortactin in growth factor receptor trafficking in breast cancer and head and neck cancers.
Paul was awarded an AstraZeneca Postdoctoral Research Fellowship allowing him to return to the Beatson Institute in 2007, to work with Professor Kurt Anderson in collaboration with AstraZeneca Advanced Technology Laboratories. This ongoing work has focused upon the development of novel multi-disciplinary live imaging techniques to investigate molecular dynamics of cancer cells in vivo.
Having returned to Australia to establish a research group in November 2012 within the Cancer Program, Paul aims to understand disease in the context of the surrounding environment using cutting edge in vitro and in vivo imaging technology. Pinpointing the molecular drivers of cancer progression and the environmental cues that cause resistance to current systemic therapy are the focus of his research.
Medical Minds Podcast
Awards
- 2023
NHMRC Investigator Grant - Australia
- 2018
NHMRC Senior Research Fellowship - Australia
- 2013
CINSW Fellowship - NSW - Sydney - Australia
- 2012
Australian Research Council (ARC) Future Fellowship - Australia
- 2011
European Association for Cancer Research Award (EACR) Australia
- 2010
Actin Prize - Bristol - UK
- 2010
Cancer Research UK - CRUK posdoctoral Research Award - UK
- 2007
AstraZeneca Research Fellowship - UK
- 2004
AMGEN Postdoctoral Early Career Research prize - Australia
- 2001
Beatson Institute PhD Career Development award - Glasgow - UK
- 2001
Cancer Research Campaign - PhD Award - London - UK
- 1998
GlaxoWellcome - University (Hons) award - Pharmacology - UK
Selected publications
See all publications- PUBLISHED 12 March 2025Science Advances
Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis
- PUBLISHED 3 July 2024Science Advances
Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response
- PUBLISHED 26 April 2023Science Advances
Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse
- PUBLISHED 29 September 2021Science Advances
Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status
- PUBLISHED 5 April 2017Science Translational Medicine
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
