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Dr Seyhan Yazar

Role
Laboratory Head
Lab/Group
Yazar Lab

Dr Yazar is a medical scientist and computational biologist with expertise in complex disease genetics, particularly as it relates to the analysis of gene-environment interactions. She holds a PhD from the University of Western Australia, which she earned in 2016 under the supervision of Professors David Mackey and Alex Hewitt. During her doctoral studies, Dr. Yazar collaborated on several research projects that focused on the design, methods, theory, and analysis of genetic and environmental factors in common complex diseases and associated traits. These projects utilised data from population-based studies. Upon the completion of her PhD, Dr. Yazar was awarded an NHMRC CJ Martin Biomedical Fellowship, which enabled her to receive specialised training in bioinformatics under the guidance of Professor Colin Semple at the MRC Human Genetics Unit of the Institute of Genetics and Molecular Medicine at the University of Edinburgh. After returning to Australia in late 2018, Dr. Yazar joined Professor Joseph Powell's laboratory at the Garvan-Weizmann Centre for Cellular Genomics, where she successfully led the first phase of the OneK1K/TenK10K project. This project focused on identifying cell-type-specific biomarkers for autoimmune diseases and translating research findings into clinical practice. Dr Yazar was recruited as a Group Leader in the Precision Immunology Program at Garvan in 2024. Her overall ambition is to develop precision biomarkers to aid clinical decision making.

Awards

  • 2024Multiple Sclerosis Australia Postdoctoral Fellowship
  • 2024The Jacqueline Goodnow and Barbara Hartley Prize
  • 2023Named in Stanford University’s List of the Top 2% of Scientists in the World
  • 2019GeneMappers Conference Best Early Career Presentation Award
  • 2018UWA Research Collaboration Award
  • 2017UWA Faculty of Health and Medical Sciences Dean’s Early Career Research Excellence Award
  • 2016NHMRC CJ Martin Biomedical Fellowship

Selected publications

See all publications
  • 2026
    BioRxiv : The Preprint Server for Biology10.64898/2026.01.20.700519

    Federated single-cell QTL meta-analysis reveals novel disease mechanisms.

    Daniel Kaptijn, Lieke Michielsen, Drew Neavin, Aida Ripoll-Cladellas, José Alquicira-Hernández, Maryna Korshevniuk, Jimmy Tsz Hang Lee, Roy Oelen, Martijn Vochteloo, Robert Warmerdam, Yoshinari Ando, Maria Ban, Odmaa Bayaraa, Marijn Berg, Irene van Blokland, Daniel Considine, Mame M Dieng, Ryuya Edahiro, M Grace Gordon, Hilde E Groot, Pim van der Harst, Matthias Heinig, Chung-Chau Hon, Youssef Idaghdour, Pooja Kathail, Niek de Klein, Wenchao Li, Yang Li, Corinna Losert, Vinu Manikanda, Jonathan Moody, Haroon Naeem, Younes Mokrab, Martijn C Nawijn, Mihai Netea, Jelmer Niewold, Yukinori Okada, Stephen Sawcer, Issiaka Soulama, Oliver Stegle, Yakov Tsepilov, Woong-Yang Park, Deepa Rajagopalan, Tala Shahin, Jay W Shin, Gosia Trynka, Urmo Võsa, Harm-Jan Westra, Seyhan Yazar, Jimmie Ye, Zhenhua Zhang, , Martin Hemberg, Ahmed Mahfouz, Marta Melé, Joseph E Powell, Marc Jan Bonder, Lude Franke, Monique G P van der Wijst
  • 2025
    American Journal of Ophthalmology10.1016/j.ajo.2025.09.042

    Association of Polygenic Scores for Glaucoma With Measures of Retinal Ganglion Cell Integrity in Young and Older Adults.

    Samantha Sze-Yee Lee, Santiago Diaz Torres, Gareth Lingham, Seyhan Yazar, Michael Hunter, Jamie E Craig, Alex W Hewitt, Stuart Macgregor, Puya Gharahkhani, David A Mackey
  • 2025
    Cell10.1016/j.cell.2025.04.005

    Macrophages direct location-dependent recall of B cell memory to vaccination.

    Rama Dhenni, Alexandra Carey Hoppé, Arnold Reynaldi, Wunna Kyaw, Nathalie Tricia Handoko, Abigail K Grootveld, Yuki Honda Keith, Nayan Deger Bhattacharyya, Holly I Ahel, Aiden Josiah Telfser, Andrew N McCorkindale, Seyhan Yazar, Christina H T Bui, James T Smith, Weng Hua Khoo, Mollie Boyd, Solange Obeid, Brad Milner, Mitchell Starr, Fabienne Brilot, Vanessa Milogiannakis, Anouschka Akerman, Anupriya Aggarwal, Miles P Davenport, Elissa K Deenick, Christine L Chaffer, Peter I Croucher, Robert Brink, Leonard D Goldstein, Deborah Cromer, Stuart G Turville, Anthony D Kelleher, Vanessa Venturi, C Mee Ling Munier, Tri Giang Phan
  • 2024
    Nat Genet.10.1038/s41588-024-01909-1

    Identifying genetic variants that influence the abundance of cell states in single-cell data

    Laurie Rumker, Saori Sakaue, Yakir Reshef, Joyce B Kang, Seyhan Yazar, Jose Alquicira-Hernandez, Cristian Valencia, Kaitlyn A Lagattuta, Annelise Mah-Som, Aparna Nathan, Joseph E Powell, Po-Ru Loh, Soumya Raychaudhuri
  • 2024
    American Journal of Ophthalmology10.1016/j.ajo.2024.05.009

    Polygenic Prediction of Keratoconus and its Measures: Cross-Sectional and Longitudinal Analyses in Community-Based Young Adults.

    Samantha Sze-Yee Lee, Santiago Diaz-Torres, Weixiong He, Seyhan Yazar, Elsie Chan, Elaine W Chong, Puya Gharahkhani, Stuart Macgregor, Gareth Lingham, David A Mackey